Assay Detail
Binding
CHEMBL3879445
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Inhibition of Saccharomyces cerevisiae alpha-glucosidase type 1 using p-nitro-phenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins followed by substrate addition measured after 5 mins every 10 secs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Quinazolinone derivatives: Synthesis and comparison of inhibitory mechanisms on α-glucosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.86 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163173 | — | — | 1 | 4.90 |
| CHEMBL2058057 | — | — | 1 | 4.81 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
| CHEMBL1432395 | — | — | 1 | - |
| CHEMBL1490787 | — | — | 1 | - |
| CHEMBL3930195 | — | — | 1 | - |
| CHEMBL1333995 | — | — | 1 | - |
| CHEMBL1164165 | — | — | 1 | - |
| CHEMBL18688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163173 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2058057 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 475000.0 | nM | - |
| CHEMBL1432395 | — | IC50 | - | — | - | |
| CHEMBL1490787 | — | IC50 | - | — | - | |
| CHEMBL3930195 | — | IC50 | - | — | - | |
| CHEMBL1333995 | — | IC50 | - | — | - | |
| CHEMBL1164165 | — | IC50 | - | — | - | |
| CHEMBL18688 | — | IC50 | > | 57200.0 | nM | - |