Assay Detail
Functional
CHEMBL3879920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at recombinant human GPR17 short isoform transfected in human 1321N1 cells assessed as mobilization of intracellular Ca2+ after 20 mins by oregon green 488 BAPTA-1/AM dye-based fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Uracil nucleotide/cysteinyl leukotriene receptor (CHEMBL1075162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GPR 17 agonists and screening assay
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.65 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3132880 | — | — | 1 | 6.71 |
| CHEMBL3132887 | — | — | 1 | 6.15 |
| CHEMBL3968577 | — | — | 1 | 6.14 |
| CHEMBL31344 | — | — | 1 | 6.09 |
| CHEMBL3915176 | — | — | 1 | 5.52 |
| CHEMBL3132885 | — | — | 1 | 5.50 |
| CHEMBL295718 | — | — | 1 | 5.43 |
| CHEMBL3132881 | — | — | 1 | 5.32 |
| CHEMBL3921330 | — | — | 1 | 5.28 |
| CHEMBL53914 | — | — | 1 | 5.13 |
| CHEMBL3897541 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3132880 | — | EC50 | = | 194.98 | nM | 6.71 |
| CHEMBL3132887 | — | EC50 | = | 707.95 | nM | 6.15 |
| CHEMBL3968577 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL31344 | — | EC50 | = | 812.83 | nM | 6.09 |
| CHEMBL3915176 | — | EC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL3132885 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL295718 | — | EC50 | = | 3715.35 | nM | 5.43 |
| CHEMBL3132881 | — | EC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL3921330 | — | EC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL53914 | — | EC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL3897541 | — | EC50 | = | 13803.84 | nM | 4.86 |