Assay Detail
Binding
CHEMBL3880086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KCl-stimulated BEC1 (unknown origin) expressed in dihydrofolate reductase-deficient CHO cells assessed as increase in release of 86Rb ion preincubated for 15 mins followed by KCl stimulation measured after 5 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH3 (CHEMBL2363017) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel pharmaceutical composition for prevention and/or treatment of attention deficit/hyperactivity disorder
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.13 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3960526 | — | — | 1 | 7.24 |
| CHEMBL3908982 | — | — | 1 | 7.19 |
| CHEMBL3979641 | — | — | 1 | 7.11 |
| CHEMBL3912592 | — | — | 1 | 7.07 |
| CHEMBL3918716 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3960526 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3908982 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3979641 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3912592 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3918716 | — | IC50 | = | 92.0 | nM | 7.04 |