Assay Detail
Functional
CHEMBL3880189
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Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.51 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3910269 | — | — | 1 | 6.13 |
| CHEMBL3894716 | — | — | 1 | 5.92 |
| CHEMBL3951270 | — | — | 1 | 5.79 |
| CHEMBL3922179 | — | — | 1 | 5.49 |
| CHEMBL3707247 | OZANIMOD | 4.0 | 1 | 5.38 |
| CHEMBL3919445 | — | — | 1 | 5.26 |
| CHEMBL3899384 | — | — | 1 | 5.10 |
| CHEMBL3902160 | — | — | 1 | 5.04 |
| CHEMBL3921214 | — | — | 1 | - |
| CHEMBL3922998 | — | — | 1 | - |
| CHEMBL3933952 | — | — | 1 | - |
| CHEMBL3931243 | — | — | 1 | - |
| CHEMBL3895230 | — | — | 1 | - |
| CHEMBL3893172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3910269 | — | EC50 | = | 739.0 | nM | 6.13 |
| CHEMBL3894716 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3951270 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3922179 | — | EC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL3707247 | OZANIMOD | EC50 | = | 4192.0 | nM | 5.38 |
| CHEMBL3919445 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3899384 | — | EC50 | = | 7866.0 | nM | 5.10 |
| CHEMBL3902160 | — | EC50 | = | 9034.0 | nM | 5.04 |
| CHEMBL3921214 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3922998 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3933952 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3931243 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3895230 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3893172 | — | EC50 | > | 10000.0 | nM | - |