Assay Detail
Binding
CHEMBL3880377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human fetal brain FLAG-tagged PRMT5/full length human testis 6His-tagged MEP50 expressed in baculovirus infected insect Sf9 cells using human histone H4 (1 to 15 residues) as substrate preincubated for 30 mins followed by [3H]-SAM addition
562
Total Activities
562
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Methods of inhibiting PRMT5
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 562 | 6.45 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3975798 | — | — | 1 | 7.00 |
| CHEMBL3964044 | — | — | 1 | 7.00 |
| CHEMBL3970875 | — | — | 1 | 7.00 |
| CHEMBL3929713 | — | — | 1 | 7.00 |
| CHEMBL3893221 | — | — | 1 | 7.00 |
| CHEMBL3907183 | — | — | 1 | 7.00 |
| CHEMBL3929701 | — | — | 1 | 7.00 |
| CHEMBL3981847 | — | — | 1 | 7.00 |
| CHEMBL3952410 | — | — | 1 | 7.00 |
| CHEMBL3955049 | — | — | 1 | 7.00 |
| CHEMBL3889494 | — | — | 1 | 7.00 |
| CHEMBL3962874 | — | — | 1 | 7.00 |
| CHEMBL3964454 | — | — | 1 | 7.00 |
| CHEMBL3928770 | — | — | 1 | 7.00 |
| CHEMBL3973363 | — | — | 1 | 7.00 |
| CHEMBL3896996 | — | — | 1 | 7.00 |
| CHEMBL3915068 | — | — | 1 | 7.00 |
| CHEMBL3905635 | — | — | 1 | 7.00 |
| CHEMBL3954078 | — | — | 1 | 7.00 |
| CHEMBL3940728 | — | — | 1 | 7.00 |
| CHEMBL3937999 | — | — | 1 | 7.00 |
| CHEMBL3891026 | — | — | 1 | 7.00 |
| CHEMBL3918772 | — | — | 1 | 7.00 |
| CHEMBL3970708 | — | — | 1 | 7.00 |
| CHEMBL3921352 | — | — | 1 | 7.00 |
| CHEMBL3983821 | — | — | 1 | 7.00 |
| CHEMBL3900173 | — | — | 1 | 7.00 |
| CHEMBL3982286 | — | — | 1 | 7.00 |
| CHEMBL3979843 | — | — | 1 | 7.00 |
| CHEMBL3922397 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3928473 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3966398 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3952615 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3926304 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3896169 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3910540 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3912990 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3974877 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3945227 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3914054 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3980870 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3962471 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3965311 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3979364 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3966235 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3929006 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3954614 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3890510 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3893239 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3908186 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3960239 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3970115 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3940321 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3968729 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3973095 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3941649 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3905430 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3964615 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3985527 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3907157 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3935766 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3938549 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3889999 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3942441 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3913350 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3912237 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3960439 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3938941 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3981786 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3898507 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3911748 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3901267 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3892082 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3899273 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3979855 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3959156 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3933483 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3963134 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3967274 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL3943231 | — | IC50 | = | 101.0 | nM | 7.00 |