PRMT5/MEP50 complex · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O14744. Use UniProt O14744 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14744 as the stable identity anchor, then attach disease evidence before program review.
Protein arginine N-methyltransferase 5
Review this target as PRMT5/MEP50 complex, mapped to UniProt O14744. ChEMBL maps the protein component as Protein arginine N-methyltransferase 5. Sequence length is 637 aa.
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This review treats PRMT5/MEP50 complex as ChEMBL target CHEMBL3137261, mapped to UniProt O14744. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | PRMT5/MEP50 complex |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O14744 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein arginine N-methyltransferase 5 |
| UniProt Accession | O14744 |
| Component Type | Protein |
| Sequence Length | 637 aa |
Protein arginine N-methyltransferase 5
Review this target as PRMT5/MEP50 complex, mapped to UniProt O14744. ChEMBL maps the protein component as Protein arginine N-methyltransferase 5. Sequence length is 637 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4563402 | 10.94 | Kd | 0.0114 | Preclinical |
| CHEMBL5426836 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4249337 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL4564327 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL5796835 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5865819 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5757382 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL4441584 | 9.62 | Kd | 0.241 | Preclinical |
| CHEMBL5790903 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL4541714 | 9.6 | IC50 | 0.25 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 73 | 1,546 | 6.5 |
| cell-based format | 65 | 750 | 6.5 |
| assay format | 19 | 150 | 7.0 |
| organism-based format | 1 | 2 | 7.3 |