Compound Detail
CHEMBL5757382
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Basic Information
| ChEMBL ID | CHEMBL5757382 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NSYXJLZEQPXXPZ-WVFSVQOHSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
429.4
MW (Da)
3.47
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PRMT5/MEP50 complex CHEMBL3137261 | IC50 | 9.68 | 7.5375 | 0.2 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PRMT5/MEP50 complex | IC50 | = | 0.21 | nM | 9.68 | Enzyme Methylation Assay: In this assay, the potency (IC50) of each compound was... | - |
| PRMT5/MEP50 complex | IC50 | = | 3.82 | nM | 8.42 | Enzyme Methylation Assay: In this assay, the potency (IC50) of each compound was... | - |
| PRMT5/MEP50 complex | IC50 | = | 172.0 | nM | 6.76 | Enzyme Methylation Assay: In this assay, the potency (IC50) of each compound was... | - |
| PRMT5/MEP50 complex | IC50 | = | 5077.0 | nM | 5.29 | Enzyme Methylation Assay: In this assay, the potency (IC50) of each compound was... | - |
Data from ChEMBL 36 via Core Engine