Assay Detail
Binding
CHEMBL3880449
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Inhibition of pig brain TRH-DE using Glp-His-ProAMC as substrate by DPP-4-based continuous fluorometric method
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Thyrotropin releasing hormone degrading enzyme (CHEMBL3988623) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.09 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3906398 | — | — | 1 | 6.39 |
| CHEMBL3926920 | — | — | 1 | 6.07 |
| CHEMBL3915933 | — | — | 1 | 5.76 |
| CHEMBL3911902 | — | — | 1 | 5.49 |
| CHEMBL3980061 | — | — | 1 | 5.18 |
| CHEMBL3921638 | — | — | 1 | 5.03 |
| CHEMBL3929592 | — | — | 1 | 5.00 |
| CHEMBL3934622 | — | — | 1 | 4.94 |
| CHEMBL3982251 | — | — | 1 | 4.93 |
| CHEMBL3954284 | — | — | 1 | 4.76 |
| CHEMBL3968057 | — | — | 1 | 4.68 |
| CHEMBL3913209 | — | — | 2 | 4.65 |
| CHEMBL314145 | — | — | 1 | 4.16 |
| CHEMBL3979818 | — | — | 1 | - |
| CHEMBL3922756 | — | — | 1 | - |
| CHEMBL3941076 | — | — | 1 | - |
| CHEMBL3940595 | — | — | 1 | - |
| CHEMBL3895280 | — | — | 1 | - |
| CHEMBL3929308 | — | — | 1 | - |
| CHEMBL3947560 | — | — | 1 | - |
| CHEMBL3897460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3906398 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3926920 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL3915933 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL3911902 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL3980061 | — | Ki | = | 6620.0 | nM | 5.18 |
| CHEMBL3921638 | — | Ki | = | 9310.0 | nM | 5.03 |
| CHEMBL3929592 | — | Ki | = | 9950.0 | nM | 5.00 |
| CHEMBL3934622 | — | Ki | = | 11590.0 | nM | 4.94 |
| CHEMBL3982251 | — | Ki | = | 11870.0 | nM | 4.93 |
| CHEMBL3954284 | — | Ki | = | 17500.0 | nM | 4.76 |
| CHEMBL3968057 | — | Ki | = | 20650.0 | nM | 4.68 |
| CHEMBL3913209 | — | Ki | = | 22370.0 | nM | 4.65 |
| CHEMBL3913209 | — | Ki | = | 63240.0 | nM | 4.20 |
| CHEMBL314145 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL3979818 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3922756 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3941076 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3940595 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3895280 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3929308 | — | Ki | = | 500000.0 | nM | - |
| CHEMBL3947560 | — | Ki | = | 356000.0 | nM | - |
| CHEMBL3897460 | — | Ki | = | 232000.0 | nM | - |