Assay Detail
Binding
CHEMBL3880642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sodium iodide symporter in rat FRTL5 cells assessed as inhibition of iodide uptake using NaI after 1 hr by arsenic/cerium sandell-Kolthoff method
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | FRTL-5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dihydropyrimidin-2(1H)-ones and dihydropyrimidin-2(1H)-thiones as inhibitors of sodium iodide symporter
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.14 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333516 | — | — | 1 | 10.19 |
| CHEMBL2333514 | — | — | 1 | 9.24 |
| CHEMBL2333504 | — | — | 1 | 9.07 |
| CHEMBL2333513 | — | — | 1 | 8.80 |
| CHEMBL2333511 | — | — | 1 | 8.49 |
| CHEMBL2333502 | — | — | 1 | 8.40 |
| CHEMBL3900988 | — | — | 1 | 7.70 |
| CHEMBL3895533 | — | — | 1 | 7.43 |
| CHEMBL3950462 | — | — | 1 | 7.40 |
| CHEMBL3908161 | — | — | 1 | 7.30 |
| CHEMBL3959979 | — | — | 1 | 7.30 |
| CHEMBL1702545 | — | — | 1 | 7.19 |
| CHEMBL3957039 | — | — | 1 | 7.19 |
| CHEMBL2333501 | — | — | 1 | 7.19 |
| CHEMBL3952962 | — | — | 1 | 7.16 |
| CHEMBL2333503 | — | — | 1 | 7.14 |
| CHEMBL2333515 | — | — | 1 | 7.12 |
| CHEMBL3894096 | — | — | 1 | 7.12 |
| CHEMBL3915394 | — | — | 1 | 7.12 |
| CHEMBL3985413 | — | — | 1 | 7.11 |
| CHEMBL1365550 | — | — | 1 | 7.10 |
| CHEMBL2333512 | — | — | 1 | 7.05 |
| CHEMBL3898213 | — | — | 1 | 7.05 |
| CHEMBL3959729 | — | — | 1 | 7.02 |
| CHEMBL3976335 | — | — | 1 | 7.00 |
| CHEMBL1644700 | SODIUM PERCHLORATE | — | 1 | 7.00 |
| CHEMBL1541261 | — | — | 1 | 6.82 |
| CHEMBL3891304 | — | — | 1 | 6.82 |
| CHEMBL277597 | — | — | 1 | 6.72 |
| CHEMBL3969249 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333516 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL2333514 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL2333504 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL2333513 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2333511 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2333502 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3900988 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3895533 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3950462 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3908161 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3959979 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3957039 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2333501 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1702545 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3952962 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2333503 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2333515 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3894096 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3915394 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3985413 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1365550 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2333512 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3898213 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3959729 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3976335 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1644700 | SODIUM PERCHLORATE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1541261 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3891304 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL277597 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3969249 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3905375 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3897972 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3966686 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1588586 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3920461 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3893753 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3907771 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3945731 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3890967 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3976099 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3974084 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3976525 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3943027 | — | IC50 | = | 1200.0 | nM | 5.92 |