Assay Detail
Binding
CHEMBL3880707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cdk2/Cyclin A (unknown origin) using retinoblastoma protein substrate and [gamma32P]ATP incubated for 15 mins by beta plate counter based assay
74
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 6.34 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140272 | — | — | 1 | 7.68 |
| CHEMBL364317 | — | — | 1 | 7.62 |
| CHEMBL3973692 | — | — | 1 | 7.37 |
| CHEMBL3935761 | — | — | 1 | 7.23 |
| CHEMBL3984345 | — | — | 1 | 7.10 |
| CHEMBL3983877 | — | — | 1 | 7.08 |
| CHEMBL3964646 | — | — | 1 | 7.02 |
| CHEMBL3960859 | — | — | 1 | 6.92 |
| CHEMBL3905466 | — | — | 1 | 6.86 |
| CHEMBL3927156 | — | — | 1 | 6.85 |
| CHEMBL3895953 | — | — | 1 | 6.75 |
| CHEMBL3897354 | — | — | 1 | 6.69 |
| CHEMBL3901003 | — | — | 1 | 6.63 |
| CHEMBL189937 | — | — | 1 | 6.36 |
| CHEMBL3958430 | — | — | 1 | 6.26 |
| CHEMBL3895697 | — | — | 1 | 6.25 |
| CHEMBL373300 | — | — | 1 | 6.08 |
| CHEMBL3941758 | — | — | 1 | 5.88 |
| CHEMBL3920898 | — | — | 1 | 5.73 |
| CHEMBL192060 | — | — | 1 | 5.60 |
| CHEMBL3931560 | — | — | 1 | 5.50 |
| CHEMBL3918866 | — | — | 1 | 5.42 |
| CHEMBL3928814 | — | — | 1 | 5.39 |
| CHEMBL189579 | — | — | 1 | 5.30 |
| CHEMBL3954838 | — | — | 1 | 5.30 |
| CHEMBL3976143 | — | — | 1 | 5.22 |
| CHEMBL3950533 | — | — | 1 | 5.22 |
| CHEMBL360675 | — | — | 1 | - |
| CHEMBL190627 | — | — | 1 | - |
| CHEMBL193184 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140272 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL364317 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3973692 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3935761 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3984345 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3983877 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3964646 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3960859 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL3905466 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL3927156 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3895953 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3897354 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3901003 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL189937 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL3958430 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL3895697 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL373300 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL3941758 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3920898 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL192060 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3931560 | — | IC50 | = | 3149.0 | nM | 5.50 |
| CHEMBL3918866 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3928814 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL189579 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL3954838 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3976143 | — | IC50 | = | 6052.0 | nM | 5.22 |
| CHEMBL3950533 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL371198 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3908855 | — | IC50 | - | — | - | |
| CHEMBL3903712 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL189490 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL192749 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL370295 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3942419 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL189978 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3907135 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL364029 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL372712 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL189543 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL189317 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL190302 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL193177 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3895532 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3979462 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL191138 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3977079 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3960034 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL193184 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL190627 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL360675 | — | IC50 | > | 5000.0 | nM | - |