Assay Detail
Binding
CHEMBL3880710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant pre-activated GST-tagged JNK2 (unknown origin) using biotinylated GST-tagged c-Jun as substrate after 120 mins in presence of 33gamma-ATP by beta scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzazole derivatives and their use as jnk modulators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.23 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3909478 | — | — | 1 | 6.68 |
| CHEMBL3899711 | — | — | 1 | 6.60 |
| CHEMBL3947385 | — | — | 1 | 6.52 |
| CHEMBL3947134 | — | — | 1 | 6.35 |
| CHEMBL1991853 | — | — | 1 | 6.30 |
| CHEMBL3911431 | — | — | 1 | 6.01 |
| CHEMBL3909574 | — | — | 1 | 5.75 |
| CHEMBL399168 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3909478 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3899711 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3947385 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3947134 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1991853 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3911431 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3909574 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL399168 | — | IC50 | = | 2300.0 | nM | 5.64 |