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Assay Detail

CHEMBL3880720

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Functional
Cytotoxicity against human HR cells assessed as reduction in cell growth after 72 hrs by MTS assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HR
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel compounds and methods of use thereof
(2003)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.46 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301318 1 8.10
CHEMBL295063 1 7.19
CHEMBL48087 1 7.11
CHEMBL3961011 1 6.89
CHEMBL3908118 1 6.58
CHEMBL3962508 1 6.54
CHEMBL46222 1 6.53
CHEMBL50280 1 6.53
CHEMBL3899298 1 6.52
CHEMBL48116 1 6.50
CHEMBL295694 1 6.49
CHEMBL45601 1 6.47
CHEMBL3920818 1 6.40
CHEMBL46330 1 6.34
CHEMBL296654 1 6.26
CHEMBL295137 1 6.14
CHEMBL3939453 1 6.13
CHEMBL3915216 1 5.65
CHEMBL3975937 1 5.53
CHEMBL3925025 1 5.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301318 IC50 = 8.0 nM 8.10
CHEMBL295063 IC50 = 64.0 nM 7.19
CHEMBL48087 IC50 = 78.0 nM 7.11
CHEMBL3961011 IC50 = 128.0 nM 6.89
CHEMBL3908118 IC50 = 266.0 nM 6.58
CHEMBL3962508 IC50 = 291.0 nM 6.54
CHEMBL46222 IC50 = 294.0 nM 6.53
CHEMBL50280 IC50 = 295.0 nM 6.53
CHEMBL3899298 IC50 = 300.0 nM 6.52
CHEMBL48116 IC50 = 316.0 nM 6.50
CHEMBL295694 IC50 = 324.0 nM 6.49
CHEMBL45601 IC50 = 340.0 nM 6.47
CHEMBL3920818 IC50 = 396.0 nM 6.40
CHEMBL46330 IC50 = 453.0 nM 6.34
CHEMBL296654 IC50 = 552.0 nM 6.26
CHEMBL295137 IC50 = 721.0 nM 6.14
CHEMBL3939453 IC50 = 739.0 nM 6.13
CHEMBL3915216 IC50 = 2250.0 nM 5.65
CHEMBL3975937 IC50 = 2984.0 nM 5.53
CHEMBL3925025 IC50 = 5456.0 nM 5.26