Assay Detail
Binding
CHEMBL3880922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Correction activity at CFTR F508 deletion mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as increase in cAMP/genistein-dependent current amplitude incubated for 10 mins at 37 degC by patch clamp method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH/3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cystic fibrosis transmembrane conductance regulator (CHEMBL4051) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indole derivatives as CFTR modulators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.44 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3897147 | — | — | 1 | 7.42 |
| CHEMBL3948182 | — | — | 1 | 7.41 |
| CHEMBL3923765 | — | — | 1 | 7.18 |
| CHEMBL3908746 | — | — | 1 | 7.09 |
| CHEMBL3898560 | — | — | 1 | 6.74 |
| CHEMBL3936630 | — | — | 1 | 6.64 |
| CHEMBL3544914 | TEZACAFTOR | 4.0 | 1 | 6.57 |
| CHEMBL3986594 | — | — | 1 | 6.55 |
| CHEMBL3933231 | — | — | 1 | 6.54 |
| CHEMBL3956217 | — | — | 1 | 6.01 |
| CHEMBL3979390 | — | — | 1 | 5.74 |
| CHEMBL3894447 | — | — | 1 | 5.51 |
| CHEMBL3897640 | — | — | 1 | 5.37 |
| CHEMBL3910383 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3897147 | — | EC50 | = | 38.1 | nM | 7.42 |
| CHEMBL3948182 | — | EC50 | = | 39.05 | nM | 7.41 |
| CHEMBL3923765 | — | EC50 | = | 65.95 | nM | 7.18 |
| CHEMBL3908746 | — | EC50 | = | 81.75 | nM | 7.09 |
| CHEMBL3898560 | — | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3936630 | — | EC50 | = | 228.5 | nM | 6.64 |
| CHEMBL3544914 | TEZACAFTOR | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL3986594 | — | EC50 | = | 283.5 | nM | 6.55 |
| CHEMBL3933231 | — | EC50 | = | 285.0 | nM | 6.54 |
| CHEMBL3956217 | — | EC50 | = | 981.0 | nM | 6.01 |
| CHEMBL3979390 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3894447 | — | EC50 | = | 3095.0 | nM | 5.51 |
| CHEMBL3897640 | — | EC50 | = | 4315.0 | nM | 5.37 |
| CHEMBL3910383 | — | EC50 | = | 4525.0 | nM | 5.34 |