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Assay Detail

CHEMBL3880928

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Functional
Antiproliferative activity against human SQ20B cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SQ20B
Confidence 1 — Organism
Curated By Autocuration

Publication

Isoform Selective HDAC Inhibitors
(2010)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.66 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL468935 1 7.00
CHEMBL387924 1 7.00
CHEMBL511212 1 7.00
CHEMBL3943242 1 6.70
CHEMBL3926370 1 6.55
CHEMBL512644 1 6.10
CHEMBL98 VORINOSTAT 4.0 1 5.52
CHEMBL389687 1 5.16
CHEMBL3966405 1 4.82
CHEMBL2417781 1 4.60
CHEMBL3914588 1 4.52
CHEMBL227170 1 4.44
CHEMBL389688 1 4.22
CHEMBL3938429 1 -
CHEMBL3947997 1 -
CHEMBL3966183 1 -
CHEMBL3905394 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL468935 IC50 = 100.0 nM 7.00
CHEMBL387924 IC50 = 100.0 nM 7.00
CHEMBL511212 IC50 = 100.0 nM 7.00
CHEMBL3943242 IC50 = 200.0 nM 6.70
CHEMBL3926370 IC50 = 280.0 nM 6.55
CHEMBL512644 IC50 = 800.0 nM 6.10
CHEMBL98 VORINOSTAT IC50 = 3000.0 nM 5.52
CHEMBL389687 IC50 = 7000.0 nM 5.16
CHEMBL3966405 IC50 = 15000.0 nM 4.82
CHEMBL2417781 IC50 = 25000.0 nM 4.60
CHEMBL3914588 IC50 = 30000.0 nM 4.52
CHEMBL227170 IC50 = 36000.0 nM 4.44
CHEMBL389688 IC50 = 60000.0 nM 4.22
CHEMBL3938429 IC50 > 60000.0 nM -
CHEMBL3947997 IC50 > 60000.0 nM -
CHEMBL3966183 IC50 > 60000.0 nM -
CHEMBL3905394 IC50 > 60000.0 nM -