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Assay Detail

CHEMBL3881040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against VEGF-stimulated HUVEC cells assessed as reduction in cell viability preincubated for 1 hr followed by addition of VEGF measured after 72 hrs by MTT assay
ChEMBL ↗
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HUVEC
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
(2003)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 76 8.45 10.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3965277 — — 1 10.30
CHEMBL3931953 — — 1 9.96
CHEMBL3899200 — — 1 9.82
CHEMBL3959357 — — 1 9.80
CHEMBL3963146 — — 1 9.74
CHEMBL3930485 — — 1 9.62
CHEMBL3899609 — — 1 9.60
CHEMBL3891895 — — 1 9.57
CHEMBL3960830 — — 1 9.44
CHEMBL3891979 — — 1 9.40
CHEMBL3978730 — — 1 9.35
CHEMBL3907423 — — 1 9.34
CHEMBL3915607 — — 1 9.32
CHEMBL1289926 AXITINIB 4.0 1 9.30
CHEMBL3921873 — — 1 9.15
CHEMBL3938361 — — 1 9.10
CHEMBL3952496 — — 1 9.10
CHEMBL3891135 — — 1 9.05
CHEMBL3894732 — — 1 9.05
CHEMBL3959310 — — 1 9.00
CHEMBL3953227 — — 1 8.89
CHEMBL3908857 — — 1 8.89
CHEMBL3968859 — — 1 8.85
CHEMBL3959522 — — 1 8.80
CHEMBL3981871 — — 1 8.72
CHEMBL3974881 — — 1 8.70
CHEMBL3956618 — — 1 8.70
CHEMBL3954085 — — 1 8.68
CHEMBL3922509 — — 1 8.66
CHEMBL3956824 — — 1 8.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3965277 — IC50 = 0.05 nM 10.30
CHEMBL3931953 — IC50 = 0.11 nM 9.96
CHEMBL3899200 — IC50 = 0.15 nM 9.82
CHEMBL3959357 — IC50 = 0.16 nM 9.80
CHEMBL3963146 — IC50 = 0.18 nM 9.74
CHEMBL3930485 — IC50 = 0.24 nM 9.62
CHEMBL3899609 — IC50 = 0.25 nM 9.60
CHEMBL3891895 — IC50 = 0.27 nM 9.57
CHEMBL3960830 — IC50 = 0.36 nM 9.44
CHEMBL3891979 — IC50 = 0.4 nM 9.40
CHEMBL3978730 — IC50 = 0.45 nM 9.35
CHEMBL3907423 — IC50 = 0.46 nM 9.34
CHEMBL3915607 — IC50 = 0.48 nM 9.32
CHEMBL1289926 AXITINIB IC50 = 0.5 nM 9.30
CHEMBL3921873 — IC50 = 0.7 nM 9.15
CHEMBL3938361 — IC50 = 0.8 nM 9.10
CHEMBL3952496 — IC50 = 0.8 nM 9.10
CHEMBL3891135 — IC50 = 0.9 nM 9.05
CHEMBL3894732 — IC50 = 0.9 nM 9.05
CHEMBL3959310 — IC50 = 1.0 nM 9.00
CHEMBL3953227 — IC50 = 1.3 nM 8.89
CHEMBL3908857 — IC50 = 1.3 nM 8.89
CHEMBL3968859 — IC50 = 1.4 nM 8.85
CHEMBL3959522 — IC50 = 1.6 nM 8.80
CHEMBL3981871 — IC50 = 1.9 nM 8.72
CHEMBL3974881 — IC50 = 2.0 nM 8.70
CHEMBL3956618 — IC50 = 2.0 nM 8.70
CHEMBL3954085 — IC50 = 2.1 nM 8.68
CHEMBL3922509 — IC50 = 2.2 nM 8.66
CHEMBL3956824 — IC50 = 2.3 nM 8.64
CHEMBL3907574 — IC50 = 2.5 nM 8.60
CHEMBL3935569 — IC50 = 2.6 nM 8.59
CHEMBL3941907 — IC50 = 2.9 nM 8.54
CHEMBL3961315 — IC50 = 3.0 nM 8.52
CHEMBL3984370 — IC50 = 3.1 nM 8.51
CHEMBL3945318 — IC50 = 3.4 nM 8.47
CHEMBL3942288 — IC50 = 3.7 nM 8.43
CHEMBL3985867 — IC50 = 3.9 nM 8.41
CHEMBL3966821 — IC50 = 4.5 nM 8.35
CHEMBL3889841 — IC50 = 4.5 nM 8.35
CHEMBL3951790 — IC50 = 4.7 nM 8.33
CHEMBL3915043 — IC50 = 4.8 nM 8.32
CHEMBL3944307 — IC50 = 4.8 nM 8.32
CHEMBL3984623 — IC50 = 4.9 nM 8.31
CHEMBL3953791 — IC50 = 6.0 nM 8.22
CHEMBL3948411 — IC50 = 6.8 nM 8.17
CHEMBL3938388 — IC50 = 8.0 nM 8.10
CHEMBL3896103 — IC50 = 8.1 nM 8.09
CHEMBL3960801 — IC50 = 8.2 nM 8.09
CHEMBL3892583 — IC50 = 8.5 nM 8.07