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Assay Detail

CHEMBL3881263

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Pseudomonas aeruginosa MPAO1 wild type apo heme oxygenase by spectrofluorimetric analysis
ChEMBL ↗
89
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Heme oxygenase (CHEMBL1075209) ↗
Type SINGLE PROTEIN
Organism Pseudomonas aeruginosa

Publication

Heme oxygenase inhibitors, screening methods for heme oxygenase inhibitors and methods of use of heme oxygenase inhibitors for antimicrobial therapy
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 89 4.71 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3952653 — — 1 5.21
CHEMBL230638 — — 1 5.21
CHEMBL3953400 — — 1 4.91
CHEMBL3913152 — — 1 4.80
CHEMBL244625 — — 1 4.80
CHEMBL395101 — — 1 4.80
CHEMBL425837 — — 1 4.80
CHEMBL395102 — — 1 4.70
CHEMBL3943112 — — 1 4.68
CHEMBL230539 — — 1 4.54
CHEMBL2429920 — — 1 4.52
CHEMBL230431 — — 1 4.47
CHEMBL1383671 — — 1 4.35
CHEMBL3915609 — — 1 4.14
CHEMBL1626462 — — 1 -
CHEMBL3960430 — — 1 -
CHEMBL3941462 — — 1 -
CHEMBL3959853 — — 1 -
CHEMBL3981732 — — 1 -
CHEMBL3941180 — — 1 -
CHEMBL3976419 — — 1 -
CHEMBL3929420 — — 1 -
CHEMBL3891385 — — 1 -
CHEMBL3979916 — — 1 -
CHEMBL1569545 CRIDANIMOD 3.0 1 -
CHEMBL3977777 — — 1 -
CHEMBL3950722 — — 1 -
CHEMBL3960344 — — 1 -
CHEMBL3944083 — — 1 -
CHEMBL3908138 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3952653 — Kd = 6100.0 nM 5.21
CHEMBL230638 — Kd = 6090.0 nM 5.21
CHEMBL3953400 — Kd = 12300.0 nM 4.91
CHEMBL3913152 — Kd = 15800.0 nM 4.80
CHEMBL244625 — Kd = 15900.0 nM 4.80
CHEMBL395101 — Kd = 15870.0 nM 4.80
CHEMBL425837 — Kd = 15790.0 nM 4.80
CHEMBL395102 — Kd = 20100.0 nM 4.70
CHEMBL3943112 — Kd = 20900.0 nM 4.68
CHEMBL230539 — Kd = 28800.0 nM 4.54
CHEMBL2429920 — Kd = 30000.0 nM 4.52
CHEMBL230431 — Kd = 33500.0 nM 4.47
CHEMBL1383671 — Kd = 44700.0 nM 4.35
CHEMBL3915609 — Kd = 72800.0 nM 4.14
CHEMBL3891014 — Kd - — -
CHEMBL3896143 — Kd - — -
CHEMBL3197209 — Kd - — -
CHEMBL3968701 — Kd - — -
CHEMBL3966412 — Kd - — -
CHEMBL3902423 — Kd - — -
CHEMBL3905093 — Kd - — -
CHEMBL3193802 — Kd - — -
CHEMBL3890666 — Kd - — -
CHEMBL3966468 — Kd - — -
CHEMBL3909440 — Kd - — -
CHEMBL1367319 — Kd - — -
CHEMBL3976665 — Kd - — -
CHEMBL1623092 — Kd - — -
CHEMBL3923092 — Kd - — -
CHEMBL3960576 — Kd - — -
CHEMBL3957915 — Kd - — -
CHEMBL3907909 — Kd - — -
CHEMBL3929420 — Kd - — -
CHEMBL3908138 — Kd - — -
CHEMBL3944083 — Kd - — -
CHEMBL3960344 — Kd - — -
CHEMBL3950722 — Kd - — -
CHEMBL3977777 — Kd - — -
CHEMBL1569545 CRIDANIMOD Kd - — -
CHEMBL3979916 — Kd - — -
CHEMBL3891385 — Kd - — -
CHEMBL3893803 — Kd - — -
CHEMBL3976419 — Kd - — -
CHEMBL3941180 — Kd - — -
CHEMBL3981732 — Kd - — -
CHEMBL3959853 — Kd - — -
CHEMBL3941462 — Kd - — -
CHEMBL3960430 — Kd - — -
CHEMBL1626462 — Kd - — -
CHEMBL3928717 — Kd - — -