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Compound Detail

CHEMBL1569545

CRIDANIMOD
🧪 Phase III
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🧪 Phase III
O=C(O)Cn1c2ccccc2c(=O)c2ccccc21
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1569545
Name CRIDANIMOD
Phase Phase III
Structure Type MOL
InChI Key UOMKBIIXHQIERR-UHFFFAOYSA-N

Known Names

Cridanimod
3
Targets
8
Activities
1
Assay Types
0
PK Parameters
12
Publications
1
Known Names
3
Indications

Molecular Properties

253.3
MW (Da)
2.24
ALogP
3
HBA
1
HBD
59.3
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral
USAN Stem -imod

Extended Properties

Molecular Formula C15H11NO3
MW 253.26
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness -0.40

Indications

Endometrial Neoplasms Endometrial Neoplasms Neoplasms

ATC Classification

L03AX18
cridanimod
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: IMMUNOSTIMULANTS

Activity Summary

Kd 8 meas. best 5.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Stimulator of interferon genes protein
CHEMBL4523311
 Kd 5.48 5.4667 3300.0 3
Unchecked
CHEMBL612545
 Kd 5.46 5.095 3500.0 4
Stimulator of interferon genes protein
CHEMBL5169097
 Kd 4.66 4.66 22000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Stimulator of interferon genes protein Kd = 3300.0 nM 5.48 Binding affinity to mouse STING by ITC assay 31820978
Stimulator of interferon genes protein Kd = 3500.0 nM 5.46 Inhibition of mouse STING by isothermal titration calorimetric method 32206239
Unchecked Kd = 3500.0 nM 5.46 Binding affinity to mouse STING R321 mutant (154 to 340 residues) assessed as di... 33360799
Stimulator of interferon genes protein Kd = 3500.0 nM 5.46 Binding affinity to mouse STING assessed as dissociation constant 35671593
Unchecked Kd = 6400.0 nM 5.19 Binding affinity to rat STING T230I V235I mutant assessed as dissociation consta... 33360799
Unchecked Kd = 7400.0 nM 5.13 Binding affinity to rat STING T230I A239V mutant assessed as dissociation consta... 33360799
Stimulator of interferon genes protein Kd = 22000.0 nM 4.66 Binding affinity to rat STING assessed as dissociation constant by isothermal ti... 33360799
Unchecked Kd = 25000.0 nM 4.6 Binding affinity to rat STING V235I/A239V double mutant assessed as dissociation... 33360799

Literature References

PubMed DOI Target Context # Activities
33360799 10.1016/j.ejmech.2020.113113 Unchecked 4
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
28666733 10.1016/j.bmcl.2017.06.035 Splenocyte 1
- 10.21203/rs.3.rs-23951/v1 SARS-CoV-2 1
- 10.1101/2020.04.21.054387 SARS-CoV-2 1
31820978 10.1021/acs.jmedchem.9b01039 Stimulator of interferon genes protein 1
32206239 10.1039/C8MD00555A Stimulator of interferon genes protein 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1
33360799 10.1016/j.ejmech.2020.113113 Stimulator of interferon genes protein 1
35671593 10.1016/j.ejmech.2022.114482 Stimulator of interferon genes protein 1

Data from ChEMBL 36 via Core Engine