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Assay Detail

CHEMBL3881488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TFPI (unknown origin) using FXa-specific chromogenic substrate S2222 incubated for 115 mins by FXa inhibition assay
ChEMBL ↗
151
Total Activities
151
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tissue factor pathway inhibitor (CHEMBL3713062) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

TFPI inhibitors and methods of use
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 151 6.21 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3894172 — — 1 7.70
CHEMBL3899635 — — 1 7.52
CHEMBL3929419 — — 1 7.40
CHEMBL3950682 — — 1 7.30
CHEMBL3975755 — — 1 7.30
CHEMBL3958046 — — 1 7.22
CHEMBL3974158 — — 1 7.22
CHEMBL3984087 — — 1 7.05
CHEMBL3980096 — — 1 7.00
CHEMBL3978085 — — 1 6.92
CHEMBL3935596 — — 1 6.89
CHEMBL3908913 — — 1 6.89
CHEMBL3969514 — — 1 6.89
CHEMBL3904040 — — 1 6.80
CHEMBL3976722 — — 1 6.80
CHEMBL3965457 — — 1 6.77
CHEMBL3926366 — — 1 6.77
CHEMBL3916916 — — 1 6.75
CHEMBL3920502 — — 1 6.75
CHEMBL3910796 — — 1 6.75
CHEMBL3961042 — — 1 6.72
CHEMBL3976800 — — 1 6.72
CHEMBL3949179 — — 1 6.70
CHEMBL3969036 — — 1 6.70
CHEMBL3892215 — — 1 6.70
CHEMBL3961378 — — 1 6.68
CHEMBL3927717 — — 1 6.68
CHEMBL3976179 — — 1 6.68
CHEMBL3958681 — — 1 6.66
CHEMBL3897272 — — 1 6.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3894172 — EC50 = 20.0 nM 7.70
CHEMBL3899635 — EC50 = 30.0 nM 7.52
CHEMBL3929419 — EC50 = 40.0 nM 7.40
CHEMBL3975755 — EC50 = 50.0 nM 7.30
CHEMBL3950682 — EC50 = 50.0 nM 7.30
CHEMBL3974158 — EC50 = 60.0 nM 7.22
CHEMBL3958046 — EC50 = 60.0 nM 7.22
CHEMBL3984087 — EC50 = 90.0 nM 7.05
CHEMBL3980096 — EC50 = 100.0 nM 7.00
CHEMBL3978085 — EC50 = 120.0 nM 6.92
CHEMBL3935596 — EC50 = 130.0 nM 6.89
CHEMBL3969514 — EC50 = 130.0 nM 6.89
CHEMBL3908913 — EC50 = 130.0 nM 6.89
CHEMBL3976722 — EC50 = 160.0 nM 6.80
CHEMBL3904040 — EC50 = 160.0 nM 6.80
CHEMBL3965457 — EC50 = 170.0 nM 6.77
CHEMBL3926366 — EC50 = 170.0 nM 6.77
CHEMBL3910796 — EC50 = 180.0 nM 6.75
CHEMBL3920502 — EC50 = 180.0 nM 6.75
CHEMBL3916916 — EC50 = 180.0 nM 6.75
CHEMBL3961042 — EC50 = 190.0 nM 6.72
CHEMBL3976800 — EC50 = 190.0 nM 6.72
CHEMBL3949179 — EC50 = 200.0 nM 6.70
CHEMBL3969036 — EC50 = 200.0 nM 6.70
CHEMBL3892215 — EC50 = 200.0 nM 6.70
CHEMBL3976179 — EC50 = 210.0 nM 6.68
CHEMBL3927717 — EC50 = 210.0 nM 6.68
CHEMBL3961378 — EC50 = 210.0 nM 6.68
CHEMBL3897272 — EC50 = 220.0 nM 6.66
CHEMBL3958681 — EC50 = 220.0 nM 6.66
CHEMBL3958468 — EC50 = 220.0 nM 6.66
CHEMBL3949739 — EC50 = 220.0 nM 6.66
CHEMBL3891294 — EC50 = 230.0 nM 6.64
CHEMBL3906782 — EC50 = 240.0 nM 6.62
CHEMBL3952366 — EC50 = 240.0 nM 6.62
CHEMBL3907128 — EC50 = 250.0 nM 6.60
CHEMBL3937934 — EC50 = 250.0 nM 6.60
CHEMBL3901896 — EC50 = 250.0 nM 6.60
CHEMBL3960826 — EC50 = 250.0 nM 6.60
CHEMBL3915524 — EC50 = 270.0 nM 6.57
CHEMBL3944655 — EC50 = 270.0 nM 6.57
CHEMBL3915051 — EC50 = 280.0 nM 6.55
CHEMBL3902697 — EC50 = 280.0 nM 6.55
CHEMBL3899092 — EC50 = 290.0 nM 6.54
CHEMBL3944404 — EC50 = 290.0 nM 6.54
CHEMBL3908454 — EC50 = 300.0 nM 6.52
CHEMBL3952104 — EC50 = 310.0 nM 6.51
CHEMBL3932312 — EC50 = 310.0 nM 6.51
CHEMBL3930464 — EC50 = 310.0 nM 6.51
CHEMBL3929337 — EC50 = 320.0 nM 6.50