Assay Detail
Binding
CHEMBL3881499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to immobilized human TFPI-1alpha assessed as inhibition of biotinylated tracer peptide JBT-0131 binding incubated for 1.5 hrs by measuring horseradish peroxidase-conjugated streptavidin-mediated conversion of TMB substrate by screening ELISA based competition assay
800
Total Activities
800
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
TFPI inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 800 | 6.79 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3894172 | — | — | 1 | 8.05 |
| CHEMBL3929419 | — | — | 1 | 7.92 |
| CHEMBL3900443 | — | — | 1 | 7.85 |
| CHEMBL3913399 | — | — | 1 | 7.80 |
| CHEMBL3903148 | — | — | 1 | 7.77 |
| CHEMBL3910006 | — | — | 1 | 7.75 |
| CHEMBL3891614 | — | — | 1 | 7.75 |
| CHEMBL3984087 | — | — | 1 | 7.75 |
| CHEMBL3893751 | — | — | 1 | 7.75 |
| CHEMBL3911436 | — | — | 1 | 7.72 |
| CHEMBL3890819 | — | — | 1 | 7.72 |
| CHEMBL3928927 | — | — | 1 | 7.70 |
| CHEMBL3941201 | — | — | 1 | 7.70 |
| CHEMBL3975304 | — | — | 1 | 7.70 |
| CHEMBL3900165 | — | — | 1 | 7.70 |
| CHEMBL3974158 | — | — | 1 | 7.70 |
| CHEMBL3920502 | — | — | 1 | 7.70 |
| CHEMBL3967876 | — | — | 1 | 7.66 |
| CHEMBL3958681 | — | — | 1 | 7.64 |
| CHEMBL3966852 | — | — | 1 | 7.64 |
| CHEMBL3910631 | — | — | 1 | 7.64 |
| CHEMBL3916916 | — | — | 1 | 7.64 |
| CHEMBL3969334 | — | — | 1 | 7.64 |
| CHEMBL3963160 | — | — | 1 | 7.64 |
| CHEMBL3890202 | — | — | 1 | 7.64 |
| CHEMBL3960575 | — | — | 1 | 7.64 |
| CHEMBL3935596 | — | — | 1 | 7.62 |
| CHEMBL3980096 | — | — | 1 | 7.62 |
| CHEMBL3958046 | — | — | 1 | 7.62 |
| CHEMBL3925868 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3894172 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3929419 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3900443 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3913399 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3903148 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3910006 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3891614 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3984087 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3893751 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3890819 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3911436 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3900165 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3928927 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3975304 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3941201 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3974158 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3920502 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3967876 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3963160 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3890202 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3958681 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3969334 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3916916 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3910631 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3960575 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3966852 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3935596 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3980096 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3958046 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3925868 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3901896 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3908913 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3962936 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3949081 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3961042 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3910796 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3904040 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3979368 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3937793 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3958468 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3927207 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3897272 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3899092 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3945603 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3896901 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3919000 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3899635 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3965457 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3923344 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3939160 | — | IC50 | = | 29.0 | nM | 7.54 |