Assay Detail
Binding
CHEMBL3881502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TFPI in FVIII inhibited human plasma assessed as reduction in thrombin generation using thrombin-specific fluorogenic substrate Z-Gly-Gly-Arg-AMC by calibrated automated thrombography
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
TFPI inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.53 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3958046 | — | — | 1 | 6.96 |
| CHEMBL3930464 | — | — | 1 | 6.92 |
| CHEMBL3929419 | — | — | 1 | 6.89 |
| CHEMBL3894172 | — | — | 1 | 6.80 |
| CHEMBL3935596 | — | — | 1 | 6.77 |
| CHEMBL3960763 | — | — | 1 | 6.68 |
| CHEMBL3891294 | — | — | 1 | 6.58 |
| CHEMBL3974158 | — | — | 1 | 6.58 |
| CHEMBL3984087 | — | — | 1 | 6.54 |
| CHEMBL3975755 | — | — | 1 | 6.50 |
| CHEMBL3932312 | — | — | 1 | 6.33 |
| CHEMBL3955549 | — | — | 1 | 6.07 |
| CHEMBL3912278 | — | — | 1 | 6.05 |
| CHEMBL3910529 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3958046 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3930464 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3929419 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3894172 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3935596 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3960763 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3891294 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3974158 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3984087 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3975755 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3932312 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3955549 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3912278 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3910529 | — | EC50 | = | 1600.0 | nM | 5.80 |