Assay Detail
Functional
CHEMBL3881585
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Cytotoxicity against human PC3 cells assessed as reduction in cell viability measured after 48 hrs by resazurin dye-based fluorometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogs of dehydrophenylahistins and their therapeutic use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.84 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | 3.0 | 1 | 9.00 |
| CHEMBL3902085 | — | — | 1 | 8.33 |
| CHEMBL3953294 | — | — | 1 | 7.88 |
| CHEMBL3928753 | — | — | 1 | 7.77 |
| CHEMBL3984744 | — | — | 1 | 7.70 |
| CHEMBL3926099 | — | — | 1 | 7.68 |
| CHEMBL3982855 | — | — | 1 | 7.60 |
| CHEMBL3930439 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096380 | PLINABULIN | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3902085 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3953294 | — | EC50 | = | 13.2 | nM | 7.88 |
| CHEMBL3928753 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3984744 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3926099 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3982855 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3930439 | — | EC50 | = | 174.0 | nM | 6.76 |