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Assay Detail

CHEMBL3881613

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against taxol-sensitive human MES-SA cells expressing MDR1 mRNA and P-gp
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MES-SA
Confidence 1 — Organism
Curated By Autocuration

Publication

Analogs of dehydrophenylahistins and their therapeutic use
(2007)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 7.79 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3953294 1 8.41
CHEMBL428647 PACLITAXEL 4.0 1 8.32
CHEMBL1096380 PLINABULIN 3.0 1 8.07
CHEMBL3984744 1 7.92
CHEMBL3982855 1 7.92
CHEMBL3926099 1 7.89
CHEMBL3928753 1 7.89
CHEMBL3890711 1 7.66
CHEMBL3902085 1 6.94
CHEMBL3930439 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3953294 EC50 = 3.9 nM 8.41
CHEMBL428647 PACLITAXEL EC50 = 4.8 nM 8.32
CHEMBL1096380 PLINABULIN EC50 = 8.5 nM 8.07
CHEMBL3984744 EC50 = 12.0 nM 7.92
CHEMBL3982855 EC50 = 12.0 nM 7.92
CHEMBL3926099 EC50 = 13.0 nM 7.89
CHEMBL3928753 EC50 = 13.0 nM 7.89
CHEMBL3890711 EC50 = 22.0 nM 7.66
CHEMBL3902085 EC50 = 116.0 nM 6.94
CHEMBL3930439 EC50 = 122.0 nM 6.91