Assay Detail
Functional
CHEMBL3881970
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Cytotoxicity against human HCT116 cells assessed as growth inhibition by measuring ATP levels after 72 hrs by ATPlite assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multi-functional small molecules as anti-proliferative agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.77 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604094 | — | — | 1 | 7.00 |
| CHEMBL596761 | — | — | 1 | 7.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.30 |
| CHEMBL598797 | CUDC-101 | 1.0 | 1 | - |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604094 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL596761 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL598797 | CUDC-101 | IC50 | <= | 50.0 | nM | - |
| CHEMBL553 | ERLOTINIB | IC50 | >= | 5000.0 | nM | - |