Assay Detail
Functional
CHEMBL3881972
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Cytotoxicity against human NCI-H1703 cells assessed as growth inhibition by measuring ATP levels after 72 hrs by ATPlite assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1703 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multi-functional small molecules as anti-proliferative agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.89 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598797 | CUDC-101 | 1.0 | 1 | 6.70 |
| CHEMBL598377 | — | — | 1 | 6.36 |
| CHEMBL3901144 | — | — | 1 | 6.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.33 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598797 | CUDC-101 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL598377 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3901144 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 8960.0 | nM | 5.05 |