Assay Detail
Binding
CHEMBL3882089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-His6-thrombin cleavage site-fused human PDGFRbeta (Arg561 to Leu1106 residues) assessed as decrease in biotinylated FLT3 phosphorylation at Tyr589 preincubated for 5 mins followed by substrate addition measured after 30 mins by DELFIA method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multi-functional small molecules as anti-proliferative agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3984522 | — | — | 1 | 7.00 |
| CHEMBL3956652 | — | — | 1 | 7.00 |
| CHEMBL3909619 | — | — | 1 | 7.00 |
| CHEMBL3973966 | — | — | 1 | 7.00 |
| CHEMBL3934468 | — | — | 1 | 7.00 |
| CHEMBL3980861 | — | — | 1 | 7.00 |
| CHEMBL3949983 | — | — | 1 | 7.00 |
| CHEMBL3940740 | — | — | 1 | - |
| CHEMBL3943406 | — | — | 1 | - |
| CHEMBL3945209 | — | — | 1 | - |
| CHEMBL3947855 | — | — | 1 | - |
| CHEMBL3907624 | — | — | 1 | - |
| CHEMBL3901629 | — | — | 1 | - |
| CHEMBL3965755 | — | — | 1 | - |
| CHEMBL3984972 | — | — | 1 | - |
| CHEMBL3889939 | — | — | 1 | - |
| CHEMBL3946124 | — | — | 1 | - |
| CHEMBL3904339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3984522 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3956652 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3909619 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3973966 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3934468 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3980861 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3949983 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3940740 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3943406 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3945209 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3947855 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3907624 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3901629 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3965755 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3984972 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3889939 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3946124 | — | IC50 | <= | 100.0 | nM | - |
| CHEMBL3904339 | — | IC50 | <= | 100.0 | nM | - |