Assay Detail
Binding
CHEMBL3882114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCV subtype 1b NS3 protease D168G mutant pre-incubated for 30 mins before TRF peptide substrate addition and measured after 1 hr by time resolved fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Macrocyclic Quinoxaline Compounds as HCV NS3 Protease Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.73 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 10.10 |
| CHEMBL3899923 | — | — | 1 | 9.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL3899923 | — | Ki | = | 0.45 | nM | 9.35 |