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Assay Detail

CHEMBL3882136

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat NHE-3-mediated Na+ dependent H+ antiport expressed in opossum kidney cells in presence of NHE-1 antagonist EIPA by BCECF-AM dye based fluorescence assay
ChEMBL ↗
73
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type kidney
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sodium/hydrogen exchanger 3 (CHEMBL3879842) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 73 5.69 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3927539 — — 1 6.00
CHEMBL3936313 — — 1 6.00
CHEMBL3891213 — — 1 6.00
CHEMBL3894386 — — 1 6.00
CHEMBL3980037 — — 1 6.00
CHEMBL3939463 — — 1 6.00
CHEMBL3980781 — — 1 6.00
CHEMBL3978422 — — 1 6.00
CHEMBL3920731 — — 1 6.00
CHEMBL3962425 — — 1 6.00
CHEMBL3967434 — — 1 6.00
CHEMBL3906248 — — 1 6.00
CHEMBL3903529 — — 1 6.00
CHEMBL3898544 — — 1 6.00
CHEMBL3939526 — — 1 6.00
CHEMBL3975615 — — 1 6.00
CHEMBL3976509 — — 1 6.00
CHEMBL3936880 — — 1 6.00
CHEMBL3915885 — — 1 6.00
CHEMBL3933988 — — 1 6.00
CHEMBL3960422 — — 1 6.00
CHEMBL3905119 — — 1 6.00
CHEMBL3901448 — — 1 6.00
CHEMBL3944964 — — 1 6.00
CHEMBL3895601 — — 1 6.00
CHEMBL3930409 — — 1 5.00
CHEMBL3970042 — — 1 5.00
CHEMBL3972692 — — 1 5.00
CHEMBL3933111 — — 1 5.00
CHEMBL3892368 — — 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3927539 — IC50 = 1000.0 nM 6.00
CHEMBL3939526 — IC50 = 1000.0 nM 6.00
CHEMBL3936313 — IC50 = 1000.0 nM 6.00
CHEMBL3891213 — IC50 = 1000.0 nM 6.00
CHEMBL3894386 — IC50 = 1000.0 nM 6.00
CHEMBL3980037 — IC50 = 1000.0 nM 6.00
CHEMBL3939463 — IC50 = 1000.0 nM 6.00
CHEMBL3980781 — IC50 = 1000.0 nM 6.00
CHEMBL3978422 — IC50 = 1000.0 nM 6.00
CHEMBL3920731 — IC50 = 1000.0 nM 6.00
CHEMBL3962425 — IC50 = 1000.0 nM 6.00
CHEMBL3967434 — IC50 = 1000.0 nM 6.00
CHEMBL3906248 — IC50 = 1000.0 nM 6.00
CHEMBL3895601 — IC50 = 1000.0 nM 6.00
CHEMBL3975615 — IC50 = 1000.0 nM 6.00
CHEMBL3976509 — IC50 = 1000.0 nM 6.00
CHEMBL3936880 — IC50 = 1000.0 nM 6.00
CHEMBL3915885 — IC50 = 1000.0 nM 6.00
CHEMBL3933988 — IC50 = 1000.0 nM 6.00
CHEMBL3960422 — IC50 = 1000.0 nM 6.00
CHEMBL3905119 — IC50 = 1000.0 nM 6.00
CHEMBL3901448 — IC50 = 1000.0 nM 6.00
CHEMBL3944964 — IC50 = 1000.0 nM 6.00
CHEMBL3898544 — IC50 = 1000.0 nM 6.00
CHEMBL3903529 — IC50 = 1000.0 nM 6.00
CHEMBL3930409 — IC50 = 10000.0 nM 5.00
CHEMBL3901018 — IC50 = 10000.0 nM 5.00
CHEMBL3950495 — IC50 = 10000.0 nM 5.00
CHEMBL3953181 — IC50 = 10000.0 nM 5.00
CHEMBL3912744 — IC50 = 10000.0 nM 5.00
CHEMBL3915431 — IC50 = 10000.0 nM 5.00
CHEMBL3892368 — IC50 = 10000.0 nM 5.00
CHEMBL3933111 — IC50 = 10000.0 nM 5.00
CHEMBL3972692 — IC50 = 10000.0 nM 5.00
CHEMBL3970042 — IC50 = 10000.0 nM 5.00
CHEMBL3895106 — IC50 = 10000.0 nM 5.00
CHEMBL3894457 — IC50 < 100.0 nM -
CHEMBL3897159 — IC50 < 100.0 nM -
CHEMBL3946770 — IC50 < 100.0 nM -
CHEMBL3956230 — IC50 < 100.0 nM -
CHEMBL3908793 — IC50 < 100.0 nM -
CHEMBL3905983 — IC50 < 100.0 nM -
CHEMBL3924640 — IC50 < 100.0 nM -
CHEMBL3921927 — IC50 < 100.0 nM -
CHEMBL3984342 — IC50 < 100.0 nM -
CHEMBL3975591 — IC50 < 100.0 nM -
CHEMBL3939056 — IC50 < 100.0 nM -
CHEMBL3936290 — IC50 < 100.0 nM -
CHEMBL3945232 — IC50 > 10000.0 nM -
CHEMBL3901000 — IC50 < 100.0 nM -