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Target Snapshot

CHEMBL3879842 Target Snapshot

Sodium/hydrogen exchanger 3 · SINGLE PROTEIN · Rattus norvegicus

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319Compounds
11Assays
2Approved Drugs
491.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P26433. Use UniProt P26433 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P26433 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium/hydrogen exchanger 3 as ChEMBL target CHEMBL3879842, mapped to UniProt P26433. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium/hydrogen exchanger 3
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3879842
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P26433
Sodium/hydrogen exchanger 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium/hydrogen exchanger 3 is the right protein anchor across sources, using UniProt P26433 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSodium/hydrogen exchanger 3
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP26433
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium/hydrogen exchanger 3
UniProt AccessionP26433
Component TypeProtein
Sequence Length831 aa

Sodium/hydrogen exchanger 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sodium/hydrogen exchanger 3, mapped to UniProt P26433. Sequence length is 831 aa.

Mapped IDP26433
Review nameSodium/hydrogen exchanger 3
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC50483.0
KI8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3965282 9.2 IC50 0.631 Preclinical
CHEMBL3926527 8.9 IC50 1.259 Preclinical
CHEMBL3897251 8.85 IC50 1.413 Preclinical
CHEMBL3960838 8.7 IC50 1.995 Preclinical
CHEMBL3937928 8.6 IC50 2.512 Preclinical
CHEMBL3968241 8.6 IC50 2.512 Preclinical
CHEMBL3976660 8.6 IC50 2.512 Preclinical
CHEMBL3990220 8.6 IC50 2.512 Preclinical
CHEMBL3894457 8.5 IC50 3.162 Preclinical
CHEMBL3932620 8.4 IC50 3.981 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
27
5.5
54
6.0
67
6.5
91
7.0
81
7.5
42
8.0
13
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TENAPANOR HYDROCHLORIDE
CHEMBL3301627
Approved 2019
Properties Compare Identifier
TENAPANOR
CHEMBL3304485
Approved 2019
Properties Compare Identifier
Assay Landscape

Assay Landscape

11
Total Assays
258
Tested Compounds
1
Assay Types
Binding — 11 assays, 258 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 254 7.0
single protein format 2 4 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine