Compound Detail
CHEMBL3301627
TENAPANOR HYDROCHLORIDE 💊 Approved Drug
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💊 Approved Drug
CN1Cc2c(Cl)cc(Cl)cc2[C@H](c2cccc(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c3cccc([C@@H]4CN(C)Cc5c(Cl)cc(Cl)cc54)c3)c2)C1.Cl.Cl
Basic Information
| ChEMBL ID | CHEMBL3301627 |
| Name | TENAPANOR HYDROCHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | VFRAXTZDILCRKY-OWRGXFNZSA-N |
| Therapeutic | ✓ Yes |
| Parent Compound | CHEMBL3304485 |
| Active Moiety | CHEMBL3304485 |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
9
Known Names
4
Indications
1
Mechanisms
Molecular Properties
1145.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2019 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium/hydrogen exchanger 3 inhibitor | INHIBITOR | Sodium/hydrogen exchanger 3 | ✓ | ✓ |
Indications
Constipation Irritable Bowel Syndrome Hyperphosphatemia Renal Insufficiency, Chronic
Drug Warnings
Black Box Warning
General Warning
Activity Summary
IC50 7 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/hydrogen exchanger 3 CHEMBL3273 | IC50 | 8.2 | 8.1333 | 6.3 | 3 |
| Sodium/hydrogen exchanger 3 CHEMBL3879842 | IC50 | 8.2 | 8.1 | 6.3 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/hydrogen exchanger 3 | IC50 | = | 6.31 | nM | 8.2 | Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossu... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 6.31 | nM | 8.2 | Inhibition of human NHE3-mediated sodium-dependant hydrogen ion antiport in Opos... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 6.31 | nM | 8.2 | Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ depend... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 6.31 | nM | 8.2 | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ depe... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossu... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ depend... | - |
| Sodium/hydrogen exchanger 3 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ depe... | - |
Data from ChEMBL 36 via Core Engine