Assay Detail
Binding
CHEMBL4257110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NHE3 expressed in OK cells assessed as reduction in Na+ dependent H+ antiport in presence of NHE1 inhibitor EIPA by BCECF-AM dye based fluorescence assay
169
Total Activities
169
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Nhe3-binding compounds and methods for inhibiting phosphate transport
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 169 | 7.56 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3942614 | — | — | 1 | 8.70 |
| CHEMBL3987020 | — | — | 1 | 8.70 |
| CHEMBL4283742 | — | — | 1 | 8.58 |
| CHEMBL3950900 | — | — | 1 | 8.55 |
| CHEMBL3954388 | — | — | 1 | 8.55 |
| CHEMBL3937928 | — | — | 1 | 8.53 |
| CHEMBL3921641 | — | — | 1 | 8.50 |
| CHEMBL3972753 | — | — | 1 | 8.45 |
| CHEMBL3968950 | — | — | 1 | 8.40 |
| CHEMBL3956501 | — | — | 1 | 8.40 |
| CHEMBL3967281 | — | — | 1 | 8.40 |
| CHEMBL3923266 | — | — | 1 | 8.40 |
| CHEMBL4279223 | — | — | 1 | 8.37 |
| CHEMBL3976345 | — | — | 1 | 8.35 |
| CHEMBL3979252 | — | — | 1 | 8.35 |
| CHEMBL3906068 | — | — | 1 | 8.30 |
| CHEMBL3304485 | TENAPANOR | 4.0 | 1 | 8.30 |
| CHEMBL3891308 | — | — | 1 | 8.30 |
| CHEMBL3911722 | — | — | 1 | 8.30 |
| CHEMBL3909990 | — | — | 1 | 8.30 |
| CHEMBL3903230 | — | — | 1 | 8.30 |
| CHEMBL3972891 | — | — | 1 | 8.30 |
| CHEMBL3965836 | — | — | 1 | 8.25 |
| CHEMBL3949556 | — | — | 1 | 8.20 |
| CHEMBL3946862 | — | — | 1 | 8.20 |
| CHEMBL3913347 | — | — | 1 | 8.20 |
| CHEMBL3954142 | — | — | 1 | 8.20 |
| CHEMBL3908976 | — | — | 1 | 8.20 |
| CHEMBL3908997 | — | — | 1 | 8.20 |
| CHEMBL4280644 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3942614 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3987020 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4283742 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL3950900 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL3954388 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL3937928 | — | IC50 | = | 2.951 | nM | 8.53 |
| CHEMBL3921641 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL3972753 | — | IC50 | = | 3.548 | nM | 8.45 |
| CHEMBL3923266 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3968950 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3967281 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3956501 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4279223 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL3976345 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL3979252 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL3304485 | TENAPANOR | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3906068 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3903230 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3909990 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3891308 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3911722 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3972891 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3965836 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL3908997 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4280644 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3946862 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4289638 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3954142 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3949556 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3908976 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3913347 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4294068 | — | IC50 | = | 7.413 | nM | 8.13 |
| CHEMBL3911951 | — | IC50 | = | 7.413 | nM | 8.13 |
| CHEMBL4291672 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3972691 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3935315 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3951502 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3970997 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4284044 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3978115 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3985915 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3901000 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3897251 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3964147 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3930643 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3301627 | TENAPANOR HYDROCHLORIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3908892 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3976660 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3941108 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3986598 | — | IC50 | = | 11.75 | nM | 7.93 |