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Target Snapshot

CHEMBL3273 Target Snapshot

Sodium/hydrogen exchanger 3 · SINGLE PROTEIN · Homo sapiens

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494Compounds
20Assays
2Approved Drugs
914.0Activities
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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Sodium/hydrogen exchanger 3 shows approved-linked disease relevance led by constipation disorder. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P48764. Start with constipation disorder, then reuse UniProt P48764 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with constipation disorder, then reuse UniProt P48764 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
constipation disorder

Sodium/hydrogen exchanger 3 shows approved-linked disease relevance led by constipation disorder. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with constipation disorder because it currently carries approved-linked support. Linked drugs include TENAPANOR HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium/hydrogen exchanger 3 as ChEMBL target CHEMBL3273, mapped to UniProt P48764. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium/hydrogen exchanger 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3273
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P48764
Sodium/hydrogen exchanger 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium/hydrogen exchanger 3 is the right protein anchor across sources, using UniProt P48764 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why constipation disorder is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSodium/hydrogen exchanger 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP48764
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium/hydrogen exchanger 3
UniProt AccessionP48764
Component TypeProtein
Sequence Length834 aa

Sodium/hydrogen exchanger 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Sodium/hydrogen exchanger 3, mapped to UniProt P48764. Sequence length is 834 aa.

Mapped IDP48764
Review nameSodium/hydrogen exchanger 3
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Sodium/hydrogen exchanger 3 shows approved-linked disease relevance led by constipation disorder. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
constipation disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugTENAPANOR HYDROCHLORIDE
Approved-linked Approved
irritable bowel syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugTENAPANOR HYDROCHLORIDE
Late clinical Phase III
age-related macular degeneration
1 linked drug · 1 direct · 1 efficacy
Linked drugSQUALAMINE LACTATE
Late clinical Phase III
macular degeneration
1 linked drug · 1 direct · 1 efficacy
Linked drugSQUALAMINE LACTATE
Clinical signal Phase II
chronic kidney disease
1 linked drug · 1 direct · 1 efficacy
Linked drugTENAPANOR HYDROCHLORIDE
Clinical signal Phase II
diabetic retinopathy
1 linked drug · 1 direct · 1 efficacy
Linked drugSQUALAMINE LACTATE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with constipation disorder because it currently carries approved-linked support. Linked drugs include TENAPANOR HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseconstipation disorder
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50914.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3904640 9.7 IC50 0.2 Preclinical
CHEMBL3304485 9.3 IC50 0.5012 Approved
CHEMBL3973684 9.3 IC50 0.5 Preclinical
CHEMBL5176968 8.9 IC50 1.259 Preclinical
CHEMBL3990220 8.8 IC50 1.585 Preclinical
CHEMBL5170002 8.8 IC50 1.585 Preclinical
CHEMBL3942614 8.7 IC50 1.995 Preclinical
CHEMBL3967635 8.7 IC50 2.0 Preclinical
CHEMBL3987020 8.7 IC50 1.995 Preclinical
CHEMBL5202545 8.7 IC50 1.995 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
25
5.5
60
6.0
73
6.5
135
7.0
155
7.5
133
8.0
26
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

TENAPANOR
CHEMBL3304485
Approved 2019
Properties Compare Identifier
TENAPANOR HYDROCHLORIDE
CHEMBL3301627
Approved 2019
Properties Compare Identifier
Assay Landscape

Assay Landscape

20
Total Assays
355
Tested Compounds
2
Assay Types
Binding — 18 assays, 355 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 350 7.4
single protein format 4 5 6.0
Functional — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 1 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine