Assay Detail
Binding
CHEMBL3882307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full-length N-terminal GST-tagged Aurora B/His-tagged INCENP (803 to 916 residues) using kemptide as substrate and [gamma33P]ATP after 45 mins by liquid scintillation counting method
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aurora kinase B/Inner centromere protein (CHEMBL3430907) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel aminopyridine derivatives having aurora a selective inhibitory action
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.72 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3951333 | — | — | 1 | 7.60 |
| CHEMBL3923139 | — | — | 1 | 7.50 |
| CHEMBL3915221 | — | — | 1 | 7.43 |
| CHEMBL3904174 | — | — | 1 | 7.41 |
| CHEMBL3958845 | — | — | 1 | 7.28 |
| CHEMBL3897985 | — | — | 1 | 7.23 |
| CHEMBL3949419 | — | — | 1 | 7.16 |
| CHEMBL3892660 | — | — | 1 | 7.02 |
| CHEMBL3889916 | — | — | 1 | 6.96 |
| CHEMBL3952770 | — | — | 1 | 6.92 |
| CHEMBL3977678 | — | — | 1 | 6.89 |
| CHEMBL3930205 | — | — | 1 | 6.89 |
| CHEMBL3967012 | — | — | 1 | 6.89 |
| CHEMBL3951876 | — | — | 1 | 6.85 |
| CHEMBL3600873 | MK-5108 | 1.0 | 1 | 6.82 |
| CHEMBL3966740 | — | — | 1 | 6.72 |
| CHEMBL3941969 | — | — | 1 | 6.70 |
| CHEMBL3929632 | — | — | 1 | 6.70 |
| CHEMBL3899823 | — | — | 1 | 6.68 |
| CHEMBL3945581 | — | — | 1 | 6.66 |
| CHEMBL3894185 | — | — | 1 | 6.50 |
| CHEMBL3939277 | — | — | 1 | 6.46 |
| CHEMBL3979540 | — | — | 1 | 6.43 |
| CHEMBL3966216 | — | — | 1 | 6.31 |
| CHEMBL3964452 | — | — | 1 | 6.18 |
| CHEMBL3914249 | — | — | 1 | 6.17 |
| CHEMBL3946400 | — | — | 1 | 6.16 |
| CHEMBL3897107 | — | — | 1 | 6.16 |
| CHEMBL3942869 | — | — | 1 | 6.15 |
| CHEMBL3976822 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3951333 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3923139 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3915221 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3904174 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3958845 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3897985 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3949419 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3892660 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3889916 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3952770 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3977678 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3967012 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3930205 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3951876 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3600873 | MK-5108 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3966740 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3941969 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3929632 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3899823 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3945581 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3894185 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3939277 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3979540 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3966216 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3964452 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3914249 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3946400 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3897107 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3942869 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3976822 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3934177 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3948611 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3891605 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3986649 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3964756 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3936303 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3955990 | — | IC50 | > | 1000.0 | nM | - |