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Assay Detail

CHEMBL3882308

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLaS3 cells assessed as cell growth inhibition after 3 days by WST-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa S3
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel aminopyridine derivatives having aurora a selective inhibitory action
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.90 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3952770 1 6.66
CHEMBL3904174 1 6.47
CHEMBL3949419 1 6.23
CHEMBL3914249 1 6.17
CHEMBL3966216 1 6.12
CHEMBL3923139 1 6.08
CHEMBL3897107 1 6.06
CHEMBL3941969 1 6.05
CHEMBL3964452 1 6.05
CHEMBL3979540 1 5.95
CHEMBL3967012 1 5.94
CHEMBL3600873 MK-5108 1.0 1 5.90
CHEMBL3948611 1 5.75
CHEMBL3915221 1 5.71
CHEMBL3951333 1 5.71
CHEMBL3966740 1 5.66
CHEMBL3899823 1 5.65
CHEMBL3976822 1 5.55
CHEMBL3934177 1 5.48
CHEMBL3897985 1 5.40
CHEMBL3958845 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3952770 IC50 = 220.0 nM 6.66
CHEMBL3904174 IC50 = 340.0 nM 6.47
CHEMBL3949419 IC50 = 590.0 nM 6.23
CHEMBL3914249 IC50 = 670.0 nM 6.17
CHEMBL3966216 IC50 = 760.0 nM 6.12
CHEMBL3923139 IC50 = 830.0 nM 6.08
CHEMBL3897107 IC50 = 870.0 nM 6.06
CHEMBL3941969 IC50 = 900.0 nM 6.05
CHEMBL3964452 IC50 = 900.0 nM 6.05
CHEMBL3979540 IC50 = 1130.0 nM 5.95
CHEMBL3967012 IC50 = 1150.0 nM 5.94
CHEMBL3600873 MK-5108 IC50 = 1260.0 nM 5.90
CHEMBL3948611 IC50 = 1760.0 nM 5.75
CHEMBL3915221 IC50 = 1930.0 nM 5.71
CHEMBL3951333 IC50 = 1970.0 nM 5.71
CHEMBL3966740 IC50 = 2210.0 nM 5.66
CHEMBL3899823 IC50 = 2220.0 nM 5.65
CHEMBL3976822 IC50 = 2800.0 nM 5.55
CHEMBL3934177 IC50 = 3300.0 nM 5.48
CHEMBL3897985 IC50 = 3950.0 nM 5.40
CHEMBL3958845 IC50 = 5890.0 nM 5.23