Assay Detail
Binding
CHEMBL3882627
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Inhibition of human ACAT1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.79 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3890942 | — | — | 1 | 6.35 |
| CHEMBL3966068 | — | — | 1 | 4.37 |
| CHEMBL55517 | DIETHYL PYROCARBONATE | — | 1 | 4.36 |
| CHEMBL461308 | MANASSANTIN B | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3890942 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3966068 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL55517 | DIETHYL PYROCARBONATE | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL461308 | MANASSANTIN B | IC50 | = | 82000.0 | nM | 4.09 |