Assay Detail
Binding
CHEMBL3882685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRA in human PANC1 cells measured after 4 days by sulforhodamine B assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted tricyclic compounds as protein kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.88 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103851 | AMUVATINIB | 2.0 | 1 | 5.52 |
| CHEMBL3914378 | — | — | 1 | 4.80 |
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 4.62 |
| CHEMBL102301 | — | — | 1 | 4.58 |
| CHEMBL3926830 | — | — | 1 | - |
| CHEMBL3924103 | — | — | 1 | - |
| CHEMBL3966621 | — | — | 1 | - |
| CHEMBL3935261 | — | — | 1 | - |
| CHEMBL456689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103851 | AMUVATINIB | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3914378 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL102301 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL3926830 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3924103 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3966621 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3935261 | — | IC50 | - | — | - | |
| CHEMBL456689 | — | IC50 | > | 50000.0 | nM | - |