Assay Detail
Binding
CHEMBL3882691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-kit (unknown origin) autophosphorylation using [gamma32P]ATP measured after 30 mins by acrylamide gel electrophoresis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted tricyclic compounds as protein kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| EC50 | 3 | 5.48 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 2 | 6.03 |
| CHEMBL3914378 | — | — | 2 | 5.92 |
| CHEMBL2103851 | AMUVATINIB | 2.0 | 2 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | EC50 | = | 942.9 | nM | 6.03 |
| CHEMBL3914378 | — | EC50 | = | 1198.0 | nM | 5.92 |
| CHEMBL2103851 | AMUVATINIB | EC50 | = | 31257.0 | nM | 4.50 |
| CHEMBL3914378 | — | Inhibition | - | % | - | |
| CHEMBL2103851 | AMUVATINIB | Inhibition | - | % | - | |
| CHEMBL1642 | IMATINIB MESYLATE | Inhibition | - | % | - |