Assay Detail
Binding
CHEMBL3882755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IGF1R kinase domain (M954 to C1367 residues) un-phosphorylated apo-enzyme form expressed in baculovirus based expression system using poly-EY peptide incubated for 2 hrs by luciferase-luciferin coupled chemiluminescent assay
527
Total Activities
526
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrimidine Derivatives As Kinase Modulators and Method of Use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 527 | 6.79 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3898928 | — | — | 1 | 7.30 |
| CHEMBL3906354 | — | — | 1 | 7.30 |
| CHEMBL3946334 | — | — | 1 | 7.30 |
| CHEMBL3932715 | — | — | 1 | 7.30 |
| CHEMBL3898581 | — | — | 1 | 7.30 |
| CHEMBL3901341 | — | — | 1 | 7.30 |
| CHEMBL505965 | — | — | 1 | 7.30 |
| CHEMBL3939181 | — | — | 1 | 7.30 |
| CHEMBL3929343 | — | — | 1 | 7.30 |
| CHEMBL3894108 | — | — | 1 | 7.30 |
| CHEMBL3891318 | — | — | 1 | 7.30 |
| CHEMBL3925505 | — | — | 1 | 7.30 |
| CHEMBL3922744 | — | — | 1 | 7.30 |
| CHEMBL3905592 | — | — | 1 | 7.30 |
| CHEMBL3917366 | — | — | 1 | 7.30 |
| CHEMBL3945893 | — | — | 1 | 7.30 |
| CHEMBL3948547 | — | — | 1 | 7.30 |
| CHEMBL3951175 | — | — | 1 | 7.30 |
| CHEMBL3904363 | — | — | 1 | 7.30 |
| CHEMBL3913406 | — | — | 1 | 7.30 |
| CHEMBL3968200 | — | — | 1 | 7.30 |
| CHEMBL3945764 | — | — | 1 | 7.30 |
| CHEMBL3907121 | — | — | 1 | 7.30 |
| CHEMBL3904364 | — | — | 1 | 7.30 |
| CHEMBL3974639 | — | — | 1 | 7.30 |
| CHEMBL3920843 | — | — | 1 | 7.30 |
| CHEMBL3911118 | — | — | 1 | 7.30 |
| CHEMBL3958377 | — | — | 1 | 7.30 |
| CHEMBL3955744 | — | — | 1 | 7.30 |
| CHEMBL3943198 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3901458 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3980941 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3983386 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3898655 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3545085 | XL-228 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3950906 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3960387 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3913123 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3949993 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3917133 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3968298 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3977566 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3907833 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3962381 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3946560 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3958220 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3954306 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3916643 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3980577 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3903938 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3913705 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3948864 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3982265 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3946183 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3963527 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3899065 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3897581 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3952875 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3923876 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3947890 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3900251 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3902986 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3941890 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3946302 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3975233 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3959585 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3962301 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3896387 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3927018 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3964210 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3889739 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3967974 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3906892 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3945357 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3942675 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3907416 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3964689 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3968474 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3905265 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3919140 | — | IC50 | = | 50.0 | nM | 7.30 |