Assay Detail
Binding
CHEMBL3887052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: Inhibition of human alpha-FXIIa was determined by the method described in [0092]-[0098] using activated human alpha-Factor XII (activated Hageman Factor) from Enzyme Research Laboratories at 50 mPEU/mL and CHA-Gly-Arg-pNA at 2 mM, 1 mM, and 0.5 mM as substrate; results are reported as Ki values (nanomolar).
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Trypsin-like serine protease inhibitors, and their preparation and use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.02 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3660189 | — | — | 1 | 6.40 |
| CHEMBL3660172 | — | — | 1 | 6.28 |
| CHEMBL3660181 | — | — | 1 | 6.26 |
| CHEMBL3660176 | — | — | 1 | 6.20 |
| CHEMBL3660175 | — | — | 1 | 6.19 |
| CHEMBL3660178 | — | — | 1 | 6.17 |
| CHEMBL3660182 | — | — | 1 | 6.10 |
| CHEMBL3660184 | — | — | 2 | 6.06 |
| CHEMBL3660174 | — | — | 1 | 5.96 |
| CHEMBL3660185 | — | — | 2 | 5.89 |
| CHEMBL3660191 | — | — | 1 | 5.82 |
| CHEMBL3660183 | — | — | 1 | 5.80 |
| CHEMBL3660180 | — | — | 1 | 5.70 |
| CHEMBL3660186 | — | — | 1 | 5.52 |
| CHEMBL3660190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3660189 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3660172 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL3660181 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL3660176 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3660175 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL3660178 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL3660182 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3660184 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL3660184 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL3660174 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3660185 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3660185 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3660191 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3660183 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3660180 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3660186 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL3660190 | — | Ki | > | 10000.0 | nM | - |