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Assay Detail

CHEMBL3887156

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
FA: fluoresence competitive assay.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Bifunctional epoxide hydrolase 2 (CHEMBL4140)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Acyl piperidine inhibitors of soluble epoxide hydrolase
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.17 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3327069 1 8.82
CHEMBL3327065 1 8.77
CHEMBL3327085 1 8.44
CHEMBL3327067 1 8.40
CHEMBL3327064 1 8.26
CHEMBL3327083 1 8.22
CHEMBL3327086 1 8.17
CHEMBL3327063 1 8.10
CHEMBL1258670 1 8.03
CHEMBL3327070 1 8.03
CHEMBL3327084 1 8.03
CHEMBL1668939 1 8.00
CHEMBL3327082 1 7.96
CHEMBL3946710 1 7.84
CHEMBL1668936 1 7.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3327069 IC50 = 1.5 nM 8.82
CHEMBL3327065 IC50 = 1.7 nM 8.77
CHEMBL3327085 IC50 = 3.6 nM 8.44
CHEMBL3327067 IC50 = 4.0 nM 8.40
CHEMBL3327064 IC50 = 5.5 nM 8.26
CHEMBL3327083 IC50 = 6.0 nM 8.22
CHEMBL3327086 IC50 = 6.8 nM 8.17
CHEMBL3327063 IC50 = 7.9 nM 8.10
CHEMBL1258670 IC50 = 9.3 nM 8.03
CHEMBL3327070 IC50 = 9.3 nM 8.03
CHEMBL3327084 IC50 = 9.3 nM 8.03
CHEMBL1668939 IC50 = 10.1 nM 8.00
CHEMBL3327082 IC50 = 11.0 nM 7.96
CHEMBL3946710 IC50 = 14.3 nM 7.84
CHEMBL1668936 IC50 = 28.9 nM 7.54