Assay Detail
Binding
CHEMBL3887285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
CB1 Receptor Binding Protocol: 8 ug of membranes (20 ul of 1:8 dilution in incubation buffer) was incubated with 5 ul of drug solution (10E-4M to 10E-12M) and 5ul of 5.4 nM [3H]CP55,940 in a total volume of 200 ul for 90 mins at 30 C. Non-specific binding was determined using 10 uM WIN55,212-2 (Ki=4.4 nM). The membranes were filtered and the filters washed 7x with 0.2 ml ice-cold incubation buffer and allowed to air dry under vacuum.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tri-aryl/heteroaromatic cannabinoids and use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.31 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3959623 | — | — | 1 | 8.63 |
| CHEMBL3923170 | — | — | 1 | 8.43 |
| CHEMBL3928596 | — | — | 1 | 7.76 |
| CHEMBL460545 | — | — | 1 | 7.57 |
| CHEMBL3915185 | — | — | 1 | 7.38 |
| CHEMBL3922001 | — | — | 1 | 7.33 |
| CHEMBL525067 | — | — | 1 | 7.03 |
| CHEMBL3950898 | — | — | 1 | 6.70 |
| CHEMBL1081624 | — | — | 1 | 6.30 |
| CHEMBL3907723 | — | — | 1 | 6.01 |
| CHEMBL460544 | — | — | 1 | - |
| CHEMBL1076685 | — | — | 1 | - |
| CHEMBL3978261 | — | — | 1 | - |
| CHEMBL3967280 | — | — | 1 | - |
| CHEMBL460754 | — | — | 1 | - |
| CHEMBL3937621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3959623 | — | Ki | = | 2.33 | nM | 8.63 |
| CHEMBL3923170 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3928596 | — | Ki | = | 17.18 | nM | 7.76 |
| CHEMBL460545 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3915185 | — | Ki | = | 41.96 | nM | 7.38 |
| CHEMBL3922001 | — | Ki | = | 46.71 | nM | 7.33 |
| CHEMBL525067 | — | Ki | = | 93.66 | nM | 7.03 |
| CHEMBL3950898 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL1081624 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL3907723 | — | Ki | = | 983.3 | nM | 6.01 |
| CHEMBL460544 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1076685 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3978261 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3967280 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL460754 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3937621 | — | Ki | > | 1000.0 | nM | - |