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Assay Detail

CHEMBL3887698

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Protease Assay: The inhibitory activity of certain compounds of Table A against HCV NS3-4A serine protease is determined in a homogenous assay using the full-length NS3-4A protein (genotype 1a, strain HCV-1) and a commercially available internally-quenched fluorogenic peptide substrate as described by Taliani, M., et al. 1996 Anal. Biochem. 240:60-67, which is incorporated by reference in its entirety.
ChEMBL ↗
203
Total Activities
201
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus genotype 1a (isolate H)
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Genome polyprotein (CHEMBL3638344) ↗
Type SINGLE PROTEIN
Organism Hepatitis C virus genotype 1a (isolate H) (HCV)

Publication

Organic compounds and their uses
(2015)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 203 8.01 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3645737 — — 1 9.30
CHEMBL3645734 — — 1 9.22
CHEMBL3645741 — — 1 9.22
CHEMBL3645729 — — 2 9.10
CHEMBL3645615 — — 1 9.05
CHEMBL3645622 — — 1 9.05
CHEMBL4109495 — — 1 9.05
CHEMBL3645619 — — 1 9.00
CHEMBL3645738 — — 1 9.00
CHEMBL3645724 — — 1 9.00
CHEMBL3645636 — — 1 9.00
CHEMBL3645606 — — 1 9.00
CHEMBL3645719 — — 1 8.96
CHEMBL3645637 — — 1 8.92
CHEMBL3645723 — — 1 8.89
CHEMBL3645629 — — 1 8.85
CHEMBL3645701 — — 1 8.85
CHEMBL3645695 — — 1 8.85
CHEMBL3645685 — — 1 8.85
CHEMBL3645667 — — 1 8.82
CHEMBL3645697 — — 1 8.82
CHEMBL3645716 — — 1 8.82
CHEMBL4107890 — — 1 8.82
CHEMBL3645736 — — 1 8.82
CHEMBL3645627 — — 1 8.77
CHEMBL3645720 — — 1 8.74
CHEMBL3645589 — — 1 8.70
CHEMBL3645602 — — 1 8.70
CHEMBL3645620 — — 1 8.70
CHEMBL3645638 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3645737 — IC50 = 0.5 nM 9.30
CHEMBL3645741 — IC50 = 0.6 nM 9.22
CHEMBL3645734 — IC50 = 0.6 nM 9.22
CHEMBL3645729 — IC50 = 0.8 nM 9.10
CHEMBL4109495 — IC50 = 0.9 nM 9.05
CHEMBL3645622 — IC50 = 0.9 nM 9.05
CHEMBL3645615 — IC50 = 0.9 nM 9.05
CHEMBL3645729 — IC50 = 0.9 nM 9.05
CHEMBL3645636 — IC50 = 1.0 nM 9.00
CHEMBL3645738 — IC50 = 1.0 nM 9.00
CHEMBL3645619 — IC50 = 1.0 nM 9.00
CHEMBL3645606 — IC50 = 1.0 nM 9.00
CHEMBL3645724 — IC50 = 1.0 nM 9.00
CHEMBL3645719 — IC50 = 1.1 nM 8.96
CHEMBL3645637 — IC50 = 1.2 nM 8.92
CHEMBL3645723 — IC50 = 1.3 nM 8.89
CHEMBL3645685 — IC50 = 1.4 nM 8.85
CHEMBL3645695 — IC50 = 1.4 nM 8.85
CHEMBL3645701 — IC50 = 1.4 nM 8.85
CHEMBL3645629 — IC50 = 1.4 nM 8.85
CHEMBL4107890 — IC50 = 1.5 nM 8.82
CHEMBL3645736 — IC50 = 1.5 nM 8.82
CHEMBL3645667 — IC50 = 1.5 nM 8.82
CHEMBL3645716 — IC50 = 1.5 nM 8.82
CHEMBL3645697 — IC50 = 1.5 nM 8.82
CHEMBL3645627 — IC50 = 1.7 nM 8.77
CHEMBL3645720 — IC50 = 1.8 nM 8.74
CHEMBL3645656 — IC50 = 2.0 nM 8.70
CHEMBL3645718 — IC50 = 2.0 nM 8.70
CHEMBL3645602 — IC50 = 2.0 nM 8.70
CHEMBL3645589 — IC50 = 2.0 nM 8.70
CHEMBL4110020 — IC50 = 2.0 nM 8.70
CHEMBL3645666 — IC50 = 2.0 nM 8.70
CHEMBL3645620 — IC50 = 2.0 nM 8.70
CHEMBL3645638 — IC50 = 2.0 nM 8.70
CHEMBL3645590 — IC50 = 2.3 nM 8.64
CHEMBL3645717 — IC50 = 2.4 nM 8.62
CHEMBL3645626 — IC50 = 2.5 nM 8.60
CHEMBL3645613 — IC50 = 2.5 nM 8.60
CHEMBL3645739 — IC50 = 2.5 nM 8.60
CHEMBL3645674 — IC50 = 2.5 nM 8.60
CHEMBL3645591 — IC50 = 2.5 nM 8.60
CHEMBL4115380 — IC50 = 2.5 nM 8.60
CHEMBL3645655 — IC50 = 2.5 nM 8.60
CHEMBL3645682 — IC50 = 2.5 nM 8.60
CHEMBL3645628 — IC50 = 2.5 nM 8.60
CHEMBL4106462 — IC50 = 2.5 nM 8.60
CHEMBL3645705 — IC50 = 2.8 nM 8.55
CHEMBL3645721 — IC50 = 2.8 nM 8.55
CHEMBL3645740 — IC50 = 3.0 nM 8.52