Assay Detail
Binding
CHEMBL3888923
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: Inhibition of various kinase enzyme.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.11 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047247 | — | — | 1 | 6.10 |
| CHEMBL1093099 | — | — | 1 | 5.55 |
| CHEMBL2047253 | — | — | 1 | 5.44 |
| CHEMBL296455 | — | — | 1 | 5.43 |
| CHEMBL2047252 | — | — | 1 | 5.19 |
| CHEMBL2047246 | — | — | 1 | 5.15 |
| CHEMBL2047245 | — | — | 1 | 5.11 |
| CHEMBL2047244 | — | — | 1 | 4.66 |
| CHEMBL2047243 | — | — | 1 | 4.37 |
| CHEMBL2047251 | — | — | 1 | 4.12 |
| CHEMBL2047248 | — | — | 1 | - |
| CHEMBL2047242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047247 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1093099 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2047253 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL296455 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL2047252 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2047246 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2047245 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2047244 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2047243 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL2047251 | — | IC50 | = | 75500.0 | nM | 4.12 |
| CHEMBL2047248 | — | IC50 | = | 126300.0 | nM | - |
| CHEMBL2047242 | — | IC50 | > | 500000.0 | nM | - |