Assay Detail
Binding
CHEMBL3991966
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Inhibition of c-Myc/Max interaction in human HL60 cells assessed as cell growth inhibition after 5 days by trypan blue exclusion assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Low molecular weight MYC-MAX inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.72 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201467 | — | — | 1 | 5.39 |
| CHEMBL4093782 | — | — | 1 | 5.34 |
| CHEMBL4086023 | — | — | 1 | 5.19 |
| CHEMBL4103943 | — | — | 1 | 5.00 |
| CHEMBL4066335 | — | — | 1 | 4.75 |
| CHEMBL255556 | — | — | 1 | 4.64 |
| CHEMBL3222133 | — | — | 1 | 4.54 |
| CHEMBL490486 | — | — | 1 | 4.44 |
| CHEMBL4071730 | — | — | 1 | 4.42 |
| CHEMBL4093899 | — | — | 1 | 4.38 |
| CHEMBL443375 | — | — | 1 | 4.31 |
| CHEMBL1958097 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201467 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4093782 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4086023 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4103943 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4066335 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL255556 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3222133 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL490486 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4071730 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4093899 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL443375 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1958097 | — | IC50 | = | 51000.0 | nM | 4.29 |