Assay Detail

CHEMBL3992018

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Functional

Potentiation of carboplatin induced DNA damage in human NCI-H647 cells expressing Rad51 assessed as carboplatin IC50 at 0.79 uM (Rvb IC50 = 172.53 uM)

ChEMBL ↗

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Target

NCI-H647 (CHEMBL614999) ↗

Open DB target context

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NCI-H647 (CHEMBL614999) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H647

CHEMBL614999

Anchored from Assay target.

Protein identity NCI-H647

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H647
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H647 (CHEMBL614999) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Pharmaceutical formulations comprising salts of a protein kinase inhibitor and methods of using same

(2013)

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.18	4.18

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2105685	AMUVATINIB HYDROCHLORIDE	-1.0	1	4.18

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2105685	AMUVATINIB HYDROCHLORIDE	IC50	=	66300.0	nM	4.18