Assay Detail
Binding
CHEMBL3993205
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Inhibition of PIM1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent Advances in Scaffold Hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.14 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 7.70 |
| CHEMBL1952107 | — | — | 1 | 7.16 |
| CHEMBL1952328 | — | — | 1 | 6.89 |
| CHEMBL1952112 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1952107 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1952328 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1952112 | — | IC50 | = | 155.0 | nM | 6.81 |