Compound Detail
CHEMBL1952328
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Basic Information
| ChEMBL ID | CHEMBL1952328 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAFJBBRUTHQHRQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
334.4
MW (Da)
3.85
ALogP
5
HBA
2
HBD
62.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 6.89 | 6.89 | 130.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 130.0 | nM | 6.89 | Inhibition of PIM1 | 22266039 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 130.0 | nM | 6.89 | Inhibition of PIM1 (unknown origin) | 28001064 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22266039 | 10.1016/j.bmcl.2011.12.130 | Serine/threonine-protein kinase pim-1 | 1 |
| 28001064 | 10.1021/acs.jmedchem.6b01437 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine