Assay Detail
Binding
CHEMBL3993540
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Inhibition of TIE-2 (unknown origin) after 60 mins by ADP-Glo assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.09 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4087541 | — | — | 1 | 9.89 |
| CHEMBL4103584 | — | — | 1 | 9.80 |
| CHEMBL4066813 | — | — | 1 | 9.22 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.08 |
| CHEMBL4085653 | — | — | 1 | 8.94 |
| CHEMBL4085495 | — | — | 1 | 8.71 |
| CHEMBL4069517 | — | — | 1 | 8.61 |
| CHEMBL4083001 | — | — | 1 | 8.46 |
| CHEMBL4092519 | — | — | 1 | 8.22 |
| CHEMBL4063920 | — | — | 1 | 8.20 |
| CHEMBL4101918 | — | — | 1 | 8.17 |
| CHEMBL4060841 | — | — | 1 | 8.01 |
| CHEMBL4086694 | — | — | 1 | 7.88 |
| CHEMBL4089043 | — | — | 1 | 7.80 |
| CHEMBL4100979 | — | — | 1 | 7.62 |
| CHEMBL4075266 | — | — | 1 | 7.30 |
| CHEMBL4080224 | — | — | 1 | 7.28 |
| CHEMBL4088100 | — | — | 1 | 7.06 |
| CHEMBL4104599 | — | — | 1 | 6.87 |
| CHEMBL4104466 | — | — | 1 | 6.78 |
| CHEMBL4093247 | — | — | 1 | 6.04 |
| CHEMBL4060113 | — | — | 1 | - |
| CHEMBL4082005 | — | — | 1 | - |
| CHEMBL4072514 | — | — | 1 | - |
| CHEMBL4071731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4087541 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4103584 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4066813 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL4085653 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL4085495 | — | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL4069517 | — | IC50 | = | 2.47 | nM | 8.61 |
| CHEMBL4083001 | — | IC50 | = | 3.49 | nM | 8.46 |
| CHEMBL4092519 | — | IC50 | = | 6.05 | nM | 8.22 |
| CHEMBL4063920 | — | IC50 | = | 6.34 | nM | 8.20 |
| CHEMBL4101918 | — | IC50 | = | 6.72 | nM | 8.17 |
| CHEMBL4060841 | — | IC50 | = | 9.68 | nM | 8.01 |
| CHEMBL4086694 | — | IC50 | = | 13.22 | nM | 7.88 |
| CHEMBL4089043 | — | IC50 | = | 15.68 | nM | 7.80 |
| CHEMBL4100979 | — | IC50 | = | 23.78 | nM | 7.62 |
| CHEMBL4075266 | — | IC50 | = | 49.97 | nM | 7.30 |
| CHEMBL4080224 | — | IC50 | = | 52.04 | nM | 7.28 |
| CHEMBL4088100 | — | IC50 | = | 87.38 | nM | 7.06 |
| CHEMBL4104599 | — | IC50 | = | 134.12 | nM | 6.87 |
| CHEMBL4104466 | — | IC50 | = | 164.35 | nM | 6.78 |
| CHEMBL4093247 | — | IC50 | = | 904.52 | nM | 6.04 |
| CHEMBL4060113 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082005 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4072514 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4071731 | — | IC50 | > | 1000.0 | nM | - |