Assay Detail
Binding
CHEMBL3993696
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Inhibition of human coagulation factor 11a using pyroGlu-Pro-Arg-pNA as substrate after 10 to 120 mins at 37 degC by spectrophotometric method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.70 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060950 | — | — | 1 | 10.52 |
| CHEMBL4071545 | — | — | 1 | 9.80 |
| CHEMBL4062923 | — | — | 1 | 9.33 |
| CHEMBL4087980 | — | — | 1 | 9.06 |
| CHEMBL3676167 | — | — | 1 | 9.00 |
| CHEMBL4090854 | — | — | 1 | 8.49 |
| CHEMBL4082071 | — | — | 1 | 8.42 |
| CHEMBL4098577 | — | — | 1 | 8.28 |
| CHEMBL3398641 | — | — | 1 | 8.24 |
| CHEMBL4079002 | — | — | 1 | 7.57 |
| CHEMBL4063872 | — | — | 1 | 7.38 |
| CHEMBL4072590 | — | — | 1 | 7.17 |
| CHEMBL4101043 | — | — | 1 | 7.12 |
| CHEMBL3699161 | — | — | 1 | 7.06 |
| CHEMBL4083064 | — | — | 1 | 6.80 |
| CHEMBL4104659 | — | — | 1 | 6.74 |
| CHEMBL4092164 | — | — | 1 | 6.58 |
| CHEMBL4059685 | — | — | 1 | 6.29 |
| CHEMBL4086754 | — | — | 1 | 6.22 |
| CHEMBL3699160 | — | — | 1 | 6.20 |
| CHEMBL4093309 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060950 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL4071545 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4062923 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL4087980 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL3676167 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4090854 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4082071 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4098577 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL3398641 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4079002 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4063872 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL4072590 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4101043 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL3699161 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL4083064 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL4104659 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4092164 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL4059685 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL4086754 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3699160 | — | Ki | = | 636.0 | nM | 6.20 |
| CHEMBL4093309 | — | Ki | = | 3920.0 | nM | 5.41 |