Assay Detail
Binding
CHEMBL3993914
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Inhibition of human recombinant carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.40 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069845 | — | — | 1 | 7.38 |
| CHEMBL4077244 | — | — | 1 | 7.19 |
| CHEMBL4096684 | — | — | 1 | 7.19 |
| CHEMBL4088398 | — | — | 1 | 7.09 |
| CHEMBL4085952 | — | — | 1 | 7.03 |
| CHEMBL4066127 | — | — | 1 | 7.03 |
| CHEMBL7087 | — | — | 1 | 7.02 |
| CHEMBL4096121 | — | — | 1 | 6.69 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4078069 | — | — | 1 | 6.59 |
| CHEMBL4103521 | — | — | 1 | 6.58 |
| CHEMBL4067135 | — | — | 1 | 6.50 |
| CHEMBL4095939 | — | — | 1 | 6.17 |
| CHEMBL4069467 | — | — | 1 | 6.13 |
| CHEMBL4085590 | — | — | 1 | 6.07 |
| CHEMBL4081098 | — | — | 1 | 6.06 |
| CHEMBL4099138 | — | — | 1 | 6.05 |
| CHEMBL4060777 | — | — | 1 | 5.44 |
| CHEMBL4088987 | — | — | 1 | 5.35 |
| CHEMBL4080175 | — | — | 1 | 5.21 |
| CHEMBL4104409 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069845 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL4077244 | — | Ki | = | 64.1 | nM | 7.19 |
| CHEMBL4096684 | — | Ki | = | 64.9 | nM | 7.19 |
| CHEMBL4088398 | — | Ki | = | 81.5 | nM | 7.09 |
| CHEMBL4085952 | — | Ki | = | 93.9 | nM | 7.03 |
| CHEMBL4066127 | — | Ki | = | 92.5 | nM | 7.03 |
| CHEMBL7087 | — | Ki | = | 94.7 | nM | 7.02 |
| CHEMBL4096121 | — | Ki | = | 206.2 | nM | 6.69 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4078069 | — | Ki | = | 255.9 | nM | 6.59 |
| CHEMBL4103521 | — | Ki | = | 264.9 | nM | 6.58 |
| CHEMBL4067135 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL4095939 | — | Ki | = | 667.9 | nM | 6.17 |
| CHEMBL4069467 | — | Ki | = | 745.6 | nM | 6.13 |
| CHEMBL4085590 | — | Ki | = | 845.2 | nM | 6.07 |
| CHEMBL4081098 | — | Ki | = | 875.4 | nM | 6.06 |
| CHEMBL4099138 | — | Ki | = | 899.4 | nM | 6.05 |
| CHEMBL4060777 | — | Ki | = | 3603.7 | nM | 5.44 |
| CHEMBL4088987 | — | Ki | = | 4450.2 | nM | 5.35 |
| CHEMBL4080175 | — | Ki | = | 6149.3 | nM | 5.21 |
| CHEMBL4104409 | — | Ki | = | 8550.9 | nM | 5.07 |