Assay Detail
Binding
CHEMBL3993916
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Inhibition of human recombinant carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.05 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067135 | — | — | 1 | 8.40 |
| CHEMBL4069845 | — | — | 1 | 7.79 |
| CHEMBL4078069 | — | — | 1 | 7.58 |
| CHEMBL4095939 | — | — | 1 | 7.51 |
| CHEMBL4096684 | — | — | 1 | 7.48 |
| CHEMBL4085590 | — | — | 1 | 7.44 |
| CHEMBL4088398 | — | — | 1 | 7.44 |
| CHEMBL4103521 | — | — | 1 | 7.43 |
| CHEMBL4060777 | — | — | 1 | 7.39 |
| CHEMBL4096121 | — | — | 1 | 7.37 |
| CHEMBL4088987 | — | — | 1 | 7.35 |
| CHEMBL4077244 | — | — | 1 | 7.34 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL4085952 | — | — | 1 | 7.10 |
| CHEMBL4099138 | — | — | 1 | 6.57 |
| CHEMBL4066127 | — | — | 1 | 6.57 |
| CHEMBL4081098 | — | — | 1 | 6.48 |
| CHEMBL7087 | — | — | 1 | 6.46 |
| CHEMBL4080175 | — | — | 1 | 5.84 |
| CHEMBL4104409 | — | — | 1 | 5.75 |
| CHEMBL4069467 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067135 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4069845 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL4078069 | — | Ki | = | 26.6 | nM | 7.58 |
| CHEMBL4095939 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL4096684 | — | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL4085590 | — | Ki | = | 36.3 | nM | 7.44 |
| CHEMBL4088398 | — | Ki | = | 36.6 | nM | 7.44 |
| CHEMBL4103521 | — | Ki | = | 36.7 | nM | 7.43 |
| CHEMBL4060777 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL4096121 | — | Ki | = | 42.8 | nM | 7.37 |
| CHEMBL4088987 | — | Ki | = | 44.7 | nM | 7.35 |
| CHEMBL4077244 | — | Ki | = | 46.1 | nM | 7.34 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL4085952 | — | Ki | = | 79.4 | nM | 7.10 |
| CHEMBL4099138 | — | Ki | = | 270.2 | nM | 6.57 |
| CHEMBL4066127 | — | Ki | = | 272.3 | nM | 6.57 |
| CHEMBL4081098 | — | Ki | = | 329.3 | nM | 6.48 |
| CHEMBL7087 | — | Ki | = | 348.8 | nM | 6.46 |
| CHEMBL4080175 | — | Ki | = | 1433.5 | nM | 5.84 |
| CHEMBL4104409 | — | Ki | = | 1799.5 | nM | 5.75 |
| CHEMBL4069467 | — | Ki | = | 2069.5 | nM | 5.68 |